Ichigo and Akeno could also be an exciting pairing. Akeno has her own unique powers and a mysterious side. Ichigo's straightforwardness and strong moral code could contrast with Akeno's more complex nature. They could work together in battles, with Ichigo providing the brute force and Akeno using her strategic and powerful attacks.
Ichigo and Rias would be a very interesting pairing. Ichigo is a powerful and determined fighter, and Rias is a strong - willed Devil. Their personalities could clash at first, but then they might find common ground in their leadership roles and their desire to protect their respective groups.
Blake Belladonna and Koneko Toujou. Both are strong female characters with a bit of a mysterious side. Blake's Faunus heritage and her experience with the White Fang could be something that Koneko, with her Nekomata powers, would be interested in. They could bond over their similarities and differences, and perhaps team up in battles against common foes.
Ichigo and Edward Elric would make an interesting pairing. Ichigo's brash and impulsive nature combined with Edward's hot - headedness yet intelligent approach could lead to some great interactions. They could learn from each other's combat styles and ways of thinking. Also, both are on a journey to protect something - Ichigo his friends and the Soul Society, and Edward his brother and his quest for the Philosopher's Stone.
Ruby and Issei would be an interesting pairing. Ruby's innocent yet determined nature combined with Issei's perverted but also heroic side could lead to some really fun and dynamic interactions. They could learn a lot from each other in terms of combat and dealing with different types of threats.
Rias Gremory would also be an interesting character to focus on. If she were to interact with Ichigo, her leadership skills and her own goals within the Highschool DxD world could be influenced. Maybe she tries to recruit Ichigo for her peerage, which would lead to all sorts of conflicts and negotiations.
Ron Weasley and Issei Hyodo could also be a fun pairing. Ron's laid - back but brave nature along with his Weasley family magic could interact interestingly with Issei's determination and his unique Sacred Gear abilities. They might start off as rivals, but then become friends as they face common enemies in the combined universe of the fanfiction.
Koneko and a god of nature could form a unique pairing. Koneko's connection to her cat - like instincts might be related to the god of nature's domain. The god could help Koneko further explore and enhance her powers, while Koneko could show the god a different perspective on the world of the supernatural that exists in the High School DxD universe.
Natsu and Akeno could have some fun interactions. Akeno has her own brand of mischief, and Natsu might not be used to her teasing ways. Their first meeting could be full of misunderstandings, with Natsu thinking she's an enemy at first because of her devious appearance, but then realizing she's an ally and developing an interesting friendship.
I think Naruto would be the most interesting. His energetic and determined personality would stand out in the Highschool DxD world. He could bring his ninja way of life and values, which are quite different from the devilish and angelic cultures in DxD. His ability to make friends easily might also lead to some really unique interactions with the DxD characters.
Naruto and Rias would be really interesting. Naruto's straightforward and determined personality combined with Rias' leadership and strategic mind could lead to some great interactions. They could learn from each other's fighting styles and ways of dealing with problems in their respective worlds.