An evil sorcerer from a forgotten age. He has knowledge of the throwing stars' true potential and wants to use them to reshape the world according to his dark vision. He uses his magic to manipulate events and people around Percy to get his hands on the stars, and he constantly tries to outwit Percy and his friends.
It could be a rogue demigod who wants the throwing stars for their power. This demigod might have been shunned by the other demigods and sees the stars as a way to gain revenge and power over them.
A powerful Titan who has escaped from Tartarus could be the main antagonist. He might be seeking revenge on Artemis for her role in the previous battles against the Titans. This Titan could have new and terrifying powers that make him a formidable foe for Percy and Artemis.
A possible main antagonist could be a rogue demigod who was once rejected by the Hunt and now wants revenge. This demigod could have allied with some powerful monsters and is constantly causing trouble for the Hunt. For example, they might be stealing important artifacts or sabotaging the Hunt's missions.
A powerful Titan who was banished to the moon in the past and now wants revenge on the gods by destroying the moon could be the main antagonist.
It could be a powerful demigod who has been corrupted by greed. He wants to use the power of the earth for his own gain, like creating his own kingdom or something. So he's trying to stop Percy from protecting the earth because Percy stands in his way.
It could be an ancient and vengeful Titan who was once imprisoned by the Hunters' predecessors. Now free, it wants to destroy the Hunters to regain its lost power and take revenge on those who once locked it away.
A powerful and corrupted nymph could be the main antagonist. She was once a friend to the Hunt but was lured to the dark side by some ancient magic. Now she wants to destroy the Hunt and take over their territory. She uses her powers over nature to create all sorts of obstacles for the Hunt and Percy, if he's involved. She could also be very manipulative, turning some of the Hunt members against each other.
Perhaps the throwing stars are cursed. Percy's guardian unknowingly passes them on to him. Percy starts having strange dreams related to the stars' origin. He has to find a way to break the curse before the stars turn him into a weapon of the dark forces. Along the way, he teams up with some of his demigod friends who help him research the history of the throwing stars and find a solution.
A powerful demigod who has been corrupted by the idea of primordial power could be the main antagonist. They might believe that by allying with a primordial or obtaining their power, they can become greater than the gods. This demigod would then oppose Percy, who stands for the protection of the current order.
An ancient and forgotten god who has been awakened. This god could be angry at the modern demigods for ignoring the old ways and decides to send assassins after Percy as a warning to the rest. They might want to bring back the old order where gods were feared and worshiped more and see Percy as a symbol of the new, more independent demigods.
Perhaps an ancient and dark deity who has been awakened due to some event related to Percy's exile. This deity wants to bring chaos to the world of gods and demigods, and Percy, even in exile, is the only one who can stop it. The deity would use all kinds of dark magic and minions to oppose Percy and his friends.