It could also be that a powerful and corrupt ninja village leader views Naruto's rise as the Uzumaki heir as a threat to his own power. He might try to manipulate other villages into opposing Naruto and the Uzumaki clan, creating a complex web of political and physical opposition for Naruto to deal with.
Perhaps an old enemy of the Uzumaki clan, long thought to be defeated, resurfaces. They see Naruto as a threat because of his position as the heir and aim to eliminate him before he can fully embrace his Uzumaki heritage and power. This could be someone with a vendetta against the Uzumaki for past events, like a clan that was defeated by the Uzumaki in the past and now wants revenge.
The Akatsuki could also be antagonists in this fanfiction. They might see the Uzumaki bloodline as a threat or as a valuable asset to their goals. So they would target Naruto not just as a jinchuriki but also as the heir of the Uzumaki clan.
Well, it could focus on Naruto exploring his Uzumaki heritage more deeply. Maybe he discovers ancient Uzumaki jutsu or artifacts that give him new powers.
Well, it could be about Naruto exploring his Uzumaki heritage more deeply. Maybe he discovers some long - lost Uzumaki jutsu or secrets that help him in battles or in uniting the ninja world.
The Akatsuki could also be antagonists in Uzumaki clan revenge fanfiction. They were after powerful ninja and the Uzumaki clan was full of power. They could have been the ones who initiated the attack on the Uzumaki clan to get their hands on things like the Uzumaki's powerful chakra or their sealing techniques. And then there might be a secret group within the Leaf Village itself that was involved in the Uzumaki clan's downfall, perhaps out of fear of their growing influence.
Another potential antagonist could be a rogue shinobi who has a vendetta against the Uzumaki clan from the past. He doesn't want to see the clan restored and uses his own dark jutsu and a network of followers to try and stop Naruto at every turn. He might be jealous of the power the Uzumaki once held and fears they will regain that power.
The main antagonists could be some of the conservative elders in the Hidden Leaf Village. They banished Naruto in the first place and would see his rebuilding of the Uzumaki clan as a threat to their power. They might try to undermine his efforts by spreading false rumors about him and his new clan.
Obviously Naruto would be one of the main characters since it's about him being the heir to the Uzumaki. Sakura and Sasuke might also be important characters as they are Naruto's friends and comrades. There could also be some original characters created specifically for the fanfiction, like an old Uzumaki sage who guides Naruto on his journey as the heir.
Danzo could be a main antagonist. He was always paranoid about the Uchiha clan's power and was involved in many of the events that led to their downfall. In a fanfiction where Naruto is trying to save the clan, Danzo would likely oppose Naruto's efforts as he sees the Uchiha as a threat to his own power and the village's stability in his own twisted way.
It could be a group within Naruto's own clan who have turned against the rest of the clan due to some ideological differences. They might want to use the clan wars as an opportunity to take over the clan and change its values. Another possibility is a mysterious and powerful ninja from another land who has his own motives for causing chaos during the clan wars.
Well, surely there would be a main Uzumaki clan member, perhaps a young and determined one. They would be the driving force behind the revenge plot. There might also be a mentor figure, an older ninja who has some knowledge about the Uzumaki clan's past and can guide the main character in their journey.