Adrien's family, especially his father if he has a complex relationship with him, would be in shock. His father might realize that his actions or the way he has been treating Adrien has pushed him to this extreme. This could lead to a change in the father's behavior or a more intense search for Adrien to bring him back home.
If there's a love interest in the fanfic, that person would be devastated. They might blame themselves for not seeing the signs that Adrien was about to run away. Their relationship would be put on hold, and they would be desperate to find him and make things right.
His friends will surely be worried. They might start looking for him everywhere, feeling sad and confused about why he left. For his closest friends, it could be a very emotional time as they fear for his safety.
Spike would be heartbroken. He's like Twilight's little brother. He depends on her for guidance and love. If she runs away, he might try to find her on his own and in the process, grow up a bit as he faces challenges alone. He could also feel abandoned and struggle with his own self - worth.
It could make Batman more determined to find him. Batman would be worried about his safety and would start an intense search. He might also feel guilty, thinking that he could have done something to prevent Tim from running away.
For Aunt May, it would be a huge shock. She has already lost so much in her life, and Peter running away would make her feel like she has failed in some way as a guardian. She would probably be constantly looking out the window, hoping to see him come back home. Also, the villains in the story could see his absence as an opportunity. They might become more bold and start causing more chaos in the city, knowing that Spider - Man is not around to stop them.
His friends would be extremely worried. Hermione, for instance, would likely try to find him using all her knowledge and resources. She'd be scouring every book and magical spell she knows to track him down. Ron would also be concerned and probably want to go after him right away, but he might be a bit more hesitant about how to actually do it.
Maybe he's tired of his restricted life. In the story, he might be feeling suffocated by all the rules and expectations placed on him, so he decides to run away to find freedom.
For her family, it could be a shock. Her parents might feel sad and regretful that they didn't have a closer relationship with her so that she could confide in them. Her siblings might also be affected, perhaps feeling a sense of loss or confusion.
It could cause a sense of loss. Harry is a symbol of hope for the wizarding community. His running away might make some people feel abandoned.
It could make them realize how much they've taken her for granted. They might have been so focused on their gifts and their own roles that they didn't notice Mirabel's pain.
For Harry, it could be a huge emotional blow. Sirius was like a father figure to him. His running away might make Harry feel abandoned again, and it could also fuel his determination to find out the truth and bring Sirius back.
His friends like Hermione and Ron would be deeply affected. They might feel abandoned at first. Hermione, being the logical one, would understand his reasons but still miss him terribly. Ron would probably be more vocal about his sadness and might even try to convince Harry to come back.