It could be that Twilight has faced some sort of rejection from her peers in the magic community. Celestia would then comfort her by emphasizing Twilight's unique talents and abilities. She would remind Twilight that she was chosen for a reason and that those who don't see her value are missing out.
It offers a chance to see the softer side of Celestia. Usually, she is seen as a powerful and somewhat distant ruler. But in this fanfiction, when she comforts Twilight, we get to see her kindness and empathy, which is really appealing.
One scenario could be that Hermione is being bullied by some pure - blood supremacists at Hogwarts for being a Muggle - born. Mrs Weasley, who has always been inclusive, finds Hermione crying in the library. She sits down with her, hugs her tightly, and tells her that her blood status doesn't define her worth. Mrs Weasley might also offer to teach Hermione some of the Weasley family's special spells to make her feel more confident.
Well, in this type of fanfiction, it might be that Twilight Sparkle is betrayed by a mentor figure. This mentor could have been teaching her false information all along, causing her to make mistakes that put her and her friends in danger. Or it could be that she is betrayed in a love - related situation. For example, if she has feelings for a certain pony and that pony pretends to reciprocate only to use her for something else, like getting access to the library in Canterlot. There are so many directions this fanfiction could take.
One possible scenario could be that Edward sacrifices himself to save Bella from a powerful new vampire threat. Another might be that he succumbs to an illness that vampires in this fanfic world are suddenly vulnerable to. Or perhaps he is killed in a battle against a group of werewolves gone rogue.
One scenario could be when Gaara is having nightmares about his past. Naruto shows up at his bedside and sits with him. He tells Gaara that he too used to have bad dreams but he learned to face his fears. Naruto then holds Gaara's hand and stays with him until he falls asleep again. Another scenario is when Gaara is feeling left out during a shinobi gathering. Naruto notices and drags him into the middle of the group, introducing him to everyone and saying how cool Gaara is. This makes Gaara feel more welcome.
Maybe Kurenai is doubting her abilities as a ninja and a teacher. Naruto then shows her all the ways she has influenced the lives of the young ninjas in Konoha. He gives her examples of how her students look up to her and how she has taught them valuable skills. Naruto's belief in her could boost her confidence.
One scenario could be that Daphne is bullied by some Slytherins for not conforming to their pure - blood ideals. Harry, having been bullied himself, steps in. He tells her that their opinions don't matter and that she is a great person regardless. He might even offer to practice defensive magic with her so she can stand up for herself.
One scenario could be that Percy has had a really tough battle and is feeling down about his performance. Thalia finds him sitting alone, and she sits beside him, tells him that everyone has off days and that his strength is more than just his combat skills. She might share some of her own insecurities and how she overcame them, making Percy feel less alone.
If Temari is feeling stressed about her role as a shinobi in diplomatic matters, Naruto could offer his own perspective. He might say 'I'm not always good at the political stuff either, but I've learned that being true to yourself and your village is the most important thing. You're doing great, and everyone can see your strength and determination.' This would boost Temari's confidence and comfort her in her role.
One possible scenario could be that Bella meets a new vampire who has a very different charm from Edward. Maybe this new vampire is more carefree and shows Bella a different side of the vampire world that she becomes attracted to, leading her to cheat in the fanfiction.