It could be Voldemort. Since he is the main bad guy in the Harry Potter series, it would make sense for him to be the antagonist. He might see the daughter of Thor as a threat to his plans of taking over the wizarding world.
Well, it could be about a character who is the daughter of Thor and somehow gets involved in the Harry Potter universe. Maybe she has special powers from being Thor's daughter like super strength or the ability to control lightning, and she uses these powers to help Harry and his friends in their battles against the dark forces in Hogwarts.
Perhaps a long - lost relative of the Potter family who feels they were unjustly excluded from inheriting the manor. This relative could be jealous of Harry's status and the wealth associated with the manor. They might use dark magic to try and claim what they think is rightfully theirs, leading to a battle of magic and loyalty within the Potter family and among Harry's friends.
Another option is a power - hungry wizard from within the Ministry of Magic. They might see Harry's daughter as a tool to gain more power. They could try to manipulate her or create situations where she is framed for things she didn't do, all in an attempt to control her and use her connection to Harry for their own political gain.
Voldemort could still be the main antagonist. Even if Demetri has some sort of connection or change in the fanfiction, Voldemort's overarching evil plans would still be a major threat to both Harry and Demetri, especially if Demetri tries to deviate from the Death Eaters' path.
The minotaur itself could be the main antagonist. It's a powerful and dangerous creature, and if it's been set loose in Hogwarts or is guarding something that Harry needs, it would be a major obstacle for him to overcome.
The main antagonist could be a dark wizard who has made the graveyard his lair. He uses the dark energy from the tombstones and the restless spirits there to power his dark magic. Harry stumbles upon this wizard's activities and has to stop him.
A new dark wizard or witch could be the main antagonist. This character, jealous of Harry's fame and power, creates a situation where Harry is framed for a heinous crime. They then ensure his arrest so that they can take over the role of the 'chosen one' in the eyes of the wizarding public and start spreading their own brand of dark magic.
It could be Malfoy. He might make fun of Harry for wearing a dress and try to use it to humiliate him in front of the whole school, which would then lead to a conflict between them that goes beyond the usual rivalry.
Perhaps a new dark wizard or witch who has infiltrated the Ministry of Magic and made sure Harry was sent to Azkaban. This antagonist could be working towards a bigger plan to take over the wizarding world and sees Harry as a major threat even when he's locked up.
Maybe a dark wizard who has an interest in Harry's newfound inheritance. This antagonist could want to steal his powers or use him for their own evil purposes. They might see Harry as a key to unlocking some ancient and powerful magic that they've been seeking.