Maybe in the fanfiction, an evil scientist creates a device that was meant to turn the turtles into humans as part of his plan to control them more easily. But once they turn human, they start to develop human emotions and relationships more strongly. They might struggle with the new feelings of love, friendship in a human context, and also figure out how to use their ninja skills in their human forms to stop the scientist's evil plans.
One possible plot could be that the turtles are exposed to a strange mutagenic substance that starts to reverse their mutation and gradually turn them human. They then have to deal with the challenges of living as humans, like going to school and fitting into society while also trying to hide their former turtle identities from those who might not understand.
It could be that there is a magical spell that gets cast on the teenage mutant ninja turtles that turns them human. As humans, they find that their memories of being turtles are still intact. They have to learn how to walk, talk, and interact like normal humans. They might also discover new powers or abilities that come with their human forms. And they have to face old enemies who are now confused by their new appearances but still determined to defeat them.