Who could be the main antagonist in a 'Luffy meets Dragon' fanfiction?

A powerful and corrupt World Noble could be the main antagonist. They might be trying to stop both Luffy and Dragon's efforts for freedom. The World Noble could have a large military force under their control and be causing chaos and oppression in various parts of the world. This would force Luffy and Dragon to join forces to take them down.

A powerful dragon - themed pirate could be the main antagonist. This pirate has a crew of dragon - like creatures and they are causing chaos across the seas. They have a grudge against Luffy for some reason, perhaps because Luffy has unknowingly entered their territory or stolen something valuable from them.

The World Government could be the main antagonist in a more complex way. They could be secretly manipulating events to pit Dragon and Luffy against each other. For example, they could spread false rumors about Luffy being a tool of the revolutionaries, which would make other pirate crews and kingdoms target him, and at the same time make Dragon look bad for having a son who is causing so much chaos. This would force Dragon and Luffy to either fight each other or find a way to clear their names together.

It could be a new character who has a deep understanding of the Goro Goro no Mi's powers and wants to use Luffy's new - found abilities for their own evil purposes. This character might be a scientist who has studied Devil Fruits extensively and sees Luffy as a prime specimen to experiment on.

An ancient sea devil who was sealed away in the past but is awakened by their time - traveling. This devil could have the power to manipulate time itself and tries to stop Luffy and Nami from returning to their own time or achieving their goals.

It could be a time - traveling pirate who has his own evil plans for the past. He might be trying to change the past to gain ultimate power in the future. So he becomes an obstacle for Luffy who wants to either preserve the past or make positive changes.

It could be a marine admiral who has developed a new weapon that not only causes physical harm but also memory loss. This admiral might see Luffy as a big threat and decides to use this weapon on him to weaken the Straw Hat crew.

Another possibility is that Death is being controlled or influenced by a greater cosmic entity. In this case, that entity could be the main antagonist. It uses Death as a tool to test or destroy the Avengers. The Avengers would then have to not only deal with Death but also find a way to face this more powerful and mysterious entity behind Death's actions.

Kingpin could be a great antagonist. He has a long history with Daredevil and his presence in Hell's Kitchen could draw Peter in. His criminal empire and power would pose a significant threat to both heroes.

A powerful Decepticon could be the main antagonist. Maybe a Decepticon named Shockwave who is on a mission to find Bumblebee and extract some important information from him. He sees Dante as an annoying obstacle in his way and tries to eliminate him. Shockwave's advanced weaponry and cold, calculating nature would pose a great threat to Dante and Bumblebee's friendship and their goals.