Well, it depends on how the fanfiction portrays it. In some cases, his friends could turn against him completely. They might see him as a danger to the wizarding world. But in more positive portrayals, they would see this as just another challenge for Harry to overcome. They would be there for him, but it would be different. For instance, they might have to help him find new ways to do magic since the vampire bite could potentially affect his magic in some ways. Their relationship would be a mix of loyalty and a new kind of understanding as they all deal with this unexpected change in Harry.
Over time, they would probably come to accept Harry for who he is. Their friendship could become even stronger as they support Harry through his new challenges. They might even start to fight for werewolf rights within the wizarding world because of Harry's situation.
On the other hand, Dumbledore could use Harry's new situation as a werewolf to his advantage in the fight against Voldemort. He might encourage Harry to embrace his werewolf side as a source of strength. This could lead to a more complex and strategic relationship, where Dumbledore sees Harry as an even more powerful weapon against the Dark Lord, but also has to balance the risks associated with Harry's new condition.
Dumbledore would be very concerned about Harry's future. He would try to guide Harry in controlling his new abilities. Their relationship might shift to a more teacher - student dynamic focused on this specific issue. Dumbledore could also use Harry's situation to teach the wizarding community a lesson about acceptance. He might encourage Harry to be open about his condition and show that being bitten doesn't make him any less of a hero. This would be a big change from their previous relationship which was more about the overall fight against Voldemort.
Harry might be more protective of his friends in the new timeline. He has seen what can happen to them in the future, so he'll do everything he can to keep them safe. With Hermione, he could encourage her to pursue her interests more freely, knowing how important her knowledge and skills will be. And with Ron, he may try to boost his confidence from the start, so Ron doesn't feel overshadowed as he did in the original timeline.
They might become closer friends. Cedric could be grateful to Harry for trying to save him during the Triwizard Tournament, and Harry would be glad that Cedric survived. They could start sharing their experiences and knowledge about magic more often, and perhaps even train together to become better wizards.
His friends might be initially confused. They're used to seeing Harry's face clearly, so a mask could create a sense of distance. Hermione, for example, would probably be very curious and try to find out the reason behind it right away. Ron, on the other hand, might be more laid - back at first but would also start to worry if Harry didn't explain soon.
In a Slytherin - Harry fanfiction, Hermione may initially distance herself from Harry. But when she realizes that Harry is still the same person deep down and that he's using his Slytherin traits for good, like using his ambition to excel in difficult subjects and his cunning to outsmart bullies. She might start to see the value in the Slytherin house and their relationship could become more of a partnership where they both learn from each other's different approaches to magic and life at Hogwarts.
His relationship with Sakura might become more of an equal partnership. Since he is now a jounin, she would respect his new rank and they could collaborate on medical - ninja and combat - related missions more effectively.
In some fanfictions, their relationships become even stronger. They have been through so much together during the war that they are like family. For example, Harry, Ron and Hermione might see each other more often and support each other in their new careers.
Harry's acceptance of his destiny would make his relationships with his friends more complex. On one hand, they would be proud of him. But on the other, they would have to adapt to his new role. His friends would need to find their own places in his journey. Hermione might focus more on researching ways to help Harry fulfill his destiny, while Ron could become more of a protector, guarding Harry from distractions. This evolution in their relationships would be a crucial part of the fanfiction's story.