A reader's cultural background can greatly influence their response. For example, in some cultures, family values are highly emphasized. So a story about a character who betrays their family may be seen as very bad. While in other cultures, individual achievement is more important.
The educational background of a reader matters too. A reader with a literary background may analyze the story from a more academic perspective, looking at things like the narrative structure and literary devices. A less educated reader may focus more on the basic plot and characters. Also, the social background affects it. A reader from a wealthy family may have a different view on a story about poverty compared to a reader from a poor family.