Perhaps in the fanfiction, the first time is when Sakura is sent to spy on Itachi. But instead of hating him as she expected, she discovers a side of Itachi that is full of pain and regret. This changes her perception of him completely and she decides to try and help him, leading to a complex relationship between them.
Fanfiction about Sakura and Itachi can be really interesting. In many such fanfictions, 'the first time' might refer to their first meeting. It could be a scenario where Sakura, with her strong will and medical ninjutsu skills, encounters Itachi, the mysterious and powerful Uchiha. This encounter could be set during a mission or by chance in Konoha. The fanfiction might explore how Sakura views Itachi's Sharingan and his brooding presence, and how Itachi perceives Sakura's determination.
One popular plot idea could be that Sakura and Itachi travel back to a crucial moment in the ninja world's history. For example, they might go back to the time when the Uchiha clan was on the verge of being massacred. Sakura, with her medical skills and modern knowledge, could try to find a non - violent solution to the Uchiha - Konoha conflict. Itachi, on the other hand, would have the chance to relive that moment and perhaps change the fate of his clan. Another idea is that they travel to the future. There, they see the consequences of the actions in their own time and try to go back and correct things in their present. This could involve seeing a destroyed Konoha and working together to prevent it.
One possible plot could be that Sakura and Itachi travel back in time to the Uchiha massacre. Itachi, having a second chance, might try to find a different way to save the Uchiha clan while still protecting Konoha. Sakura, with her medical skills and knowledge of future events, could assist him. For example, she could help him find evidence to prove the Uchiha's innocence to the village elders, thus preventing the massacre from happening at all.
A plot could involve Sakura getting caught in a political intrigue within the Anbu that Itachi is also a part of. Itachi tries to keep Sakura out of it, but she's determined to uncover the truth. This leads to a series of events where they have to rely on each other's strengths and overcome their own weaknesses.
Another plot idea could be that the contract was made by an ancient force and it requires them to go on a quest to find a lost artifact. Along the way, they face many challenges and their relationship changes from initial distrust to a strong friendship or even something more. They have to rely on each other's strengths and overcome their weaknesses.
One plot idea could be that Sakura, as a medic in the Anbu, is assigned to a mission with Itachi. They initially have some misunderstandings due to their different personalities. Sakura is outspoken and Itachi is more reserved. But as the mission progresses, they start to understand and respect each other's skills. Sakura learns from Itachi's stealth and combat techniques, while Itachi comes to appreciate Sakura's medical knowledge and her tenacity in difficult situations.
One idea could be that Itachi is a new transfer student in Sakura's highschool. Sakura, being the studious and kind - hearted girl she is, is assigned to help Itachi catch up with the lessons. This could lead to them gradually developing a friendship and maybe more as they discover each other's secrets and talents.
A plot could involve Itachi's spirit being re - summoned in a way that only Sakura can interact with. Sakura, with her medical knowledge, tries to find a way to bring Itachi back to life fully. During this time, they share many memories and Sakura starts to consider Itachi as part of her family. The story could then revolve around Sakura's attempts and the consequences it might have on the ninja world.
In a high school fanfiction, perhaps Itachi is a new transfer student. Sakura, being the curious and friendly girl she is, decides to befriend him. They end up getting paired for a school project. At first, Itachi is quiet and reserved, but as they work together, Sakura discovers his hidden depths and he starts to open up to her more. This could create a really interesting dynamic between them.
One plot idea could be that Itachi and Shisui are on a mission and they cross paths with Sakura. Shisui, being the friendly one, starts to teach Sakura some new jutsu skills. Itachi, initially reluctant, gradually warms up to Sakura's determination. Another could be a time - travel plot where Sakura goes back in time and meets a young Itachi and Shisui. She tries to prevent some of the tragedies that are to befall them in the future. And finally, a plot where Itachi and Shisui are in a life - or - death situation and Sakura, with her medical skills, has to save them and in the process, they form a strong bond.