It would have a huge impact. His friends would be in shock. They've always counted on Naruto to be himself. With Orochimaru's influence, Naruto might turn against them. His relationships would become strained. Shikamaru, being the intelligent one, would probably try to figure out a way to reverse the brainwashing. But until then, Naruto's bond with his friends would be on the verge of breaking. His friends would have to decide whether to fight him or try to save him, which is a really tough situation for them.
Well, his friends would likely be very confused and hurt. They know Naruto as a determined and kind - hearted person. If he's brainwashed, they might initially try to reach out to him, thinking it's just a temporary state. But as time goes on, they could become distrustful if he starts to act against them. Sasuke, for example, might be even more conflicted, seeing Naruto in such a different state. And Sakura would be heartbroken, as Naruto has always been a source of hope and friendship for her.
Well, it would be a huge blow to his friendships. Naruto's friends are drawn to his big heart and strong emotions. An emotionless Naruto would not respond in the same warm way. He might not share in their joys or sorrows. Sakura, for instance, would miss his determination and the way he used to encourage her. His friends would have to work hard to reach out to him, but they may also start to drift apart because the emotional connection is no longer there.
With his friends in Konoha, they would be worried and perhaps a bit afraid. They know Orochimaru's reputation as a villain. Naruto's friends like Shikamaru might start to keep a closer eye on him, which Naruto could resent. He would feel like they don't trust him anymore, and this could strain their friendships.
With Shikamaru, Naruto's early Rasengan might make Shikamaru more interested in teaming up with him. Shikamaru is smart and he would recognize the potential of having Naruto with his powerful jutsu on their side for missions. So they could form a stronger bond based on mutual respect for each other's abilities.
Naruto's relationship with Kakashi could also change. Kakashi, being a more experienced ninja, would try to guide Naruto in using the Millennium Puzzle's power responsibly. He might teach Naruto about the potential dangers of misusing such a powerful artifact, which could bring them closer as teacher and student. Naruto's friends in Team 7 would also look to him for more leadership when they see the power the Puzzle gives him.
Naruto's dragon blood could also attract new friends or allies. There could be characters from other clans or regions who are interested in his powers and want to be associated with him. This could cause some friction among his old friends at first, but eventually they would come to accept these new relationships as long as Naruto remains true to his original friends. His relationships would become more complex and diverse, but still centered around the core values of friendship that Naruto has always held.
It would likely strain his relationship with Sasuke. Sasuke has his own complex history with Orochimaru, and if Naruto becomes a fan, Sasuke would be very confused and probably angry. He might see Naruto as betraying their shared values. As for his friends in Konoha, they would also be worried and try to talk Naruto out of it, which could lead to some arguments and a rift in their friendships.
It would have a huge negative impact. Naruto's friends have come to rely on his emotional support and his ability to inspire them. Without his emotions, he might not show the same enthusiasm in helping them. His friendship with Kakashi would also change as Kakashi has guided Naruto in part based on his emotions and his will to protect his friends. Naruto might seem distant and unresponsive, causing his friends to feel rejected.
Well, in such fanfiction, Harry's neglect by his parents can cause him to have a deep - seated fear of abandonment in his friendships. This could lead to him constantly testing his friends' loyalty. On the other hand, his friends, if they are true friends, will be more patient with him and try to show him unconditional love, which in turn can strengthen their relationships in the long run.
Some friends might feel betrayed. If they are very clan - oriented, they could see Naruto's leaving as a sign that he doesn't value the clan and by extension, their friendship. However, his true friends like Sasuke or Sakura might understand his reasons. Sasuke, who has his own issues with his clan, might be more empathetic. Sakura, who has seen Naruto's determination, could support his decision in the long run.
When the Kyuubi possesses Naruto, his friends' trust in him is tested. Some, like Shikamaru, might be more cautious and try to keep an eye on Naruto to make sure he doesn't go out of control. Others, like Choji, might be more sympathetic and try to offer Naruto support. This possession changes the dynamics. Naruto might feel isolated as his friends struggle to understand what's going on with him, and it takes time for them to rebuild their normal relationships.