One possible plotline could be that they leave to seek a new form of power. Maybe they've discovered a threat that the Hidden Leaf isn't aware of, and they believe they can find a solution outside. Another could be that they're on a journey of self - discovery. Sakura has always been in Sasuke's shadow to some extent, and this could be her chance to truly find herself while being with him. Also, perhaps they leave due to some political unrest in Konoha that they don't want to be a part of.
One possible plotline could be that Sakura decides to raise the child on her own. She focuses on her medical ninjutsu to provide for the baby. Another could be that she tries to find Sasuke again to make him take responsibility. Maybe she faces challenges from the village as a single mother, but her friends support her through it all.
A plotline might involve Sakura facing a lot of judgment from the village. But she stands strong and raises the child with the help of her friends like Naruto and Ino. They support her emotionally and sometimes even materially. As for Sasuke, he might be on a journey of self - discovery and when he hears about the pregnancy, he has to decide whether his path still lies away from Konoha and his family or if he should change his ways.
One possible plot could be that they leave Konoha due to a new threat that the village is unable or unwilling to face. They might go on a journey to find a way to defeat this threat on their own. Along the way, they could face many challenges that test their friendship and skills.
They might leave to seek new forms of power or knowledge. There could be things outside of Konoha that they believe will help them become better at their ninja skills. For instance, they might have heard of a special dojo or a hidden scroll in another land that could enhance their abilities.
They could be leaving in search of new training opportunities. Konoha might not offer the advanced or specialized training they seek. So, they decide to leave to find a place where they can grow stronger and expand their abilities.
Sasuke might initially be shocked. He has always seen Sakura as someone connected to Konoha, so her leaving would be unexpected. He could be concerned about her safety, especially if she leaves without proper preparation or protection.
One possible plotline could be that Sakura leaves Konoha due to a personal quest for self - discovery. She might feel that she has outgrown the village or that there are things she can't achieve while staying there. For example, she could be in search of a new medical ninjutsu technique that can only be found in a far - off land. Along the way, Sasuke might cross her path, and they could either have a moment of reconciliation or further conflict depending on their respective states of mind.
One possible reason could be that Sakura realizes Sasuke is on a path she can't follow. Maybe he's too consumed by his revenge and she decides it's better for her own well - being to leave him be. In some fanfictions, she might also find someone else who values her more and she chooses to focus on that new relationship instead of chasing after Sasuke.
At the beginning, their relationship might be a bit rocky. Sasuke is used to being alone, and Sakura has to adjust to his way of doing things. However, as they face challenges together, like fighting off enemy ninjas or surviving in harsh environments, they start to bond. Sakura's constant support and her growth as a ninja start to make Sasuke respect her more. Eventually, this respect could lead to a more intimate relationship where they truly open up to each other.
A possible plotline could be that they are both on a mission to rescue their kidnapped comrades. They have to work together, using their unique ninja skills. Female Sasuke with her lightning - fast attacks and Sakura with her super - strong punches.