Definitely Sakura is the central figure. But we could also see the appearance of Ino. Since she and Sakura have a complex relationship, her presence could add some emotional drama. Shikamaru might be involved too. His strategic mind could be crucial in figuring out what's going on in the void. Kiba and Akamaru could show up, using their tracking skills to help Sakura understand the nature of the void. And perhaps some old enemies of Konoha who have some connection to the creation of the void could also make an appearance.
In this fanfiction, when Sakura wakes up in the Konoha forest void, it could be that she is the only one who can sense the true nature of the void. Perhaps it is not just an empty space but a gateway to another dimension or a prison for some powerful entity. She may start a journey to either close the gateway or free the entity if it is proven to be good. This would involve her using her medical ninjutsu knowledge in combination with her combat skills to deal with any threats that come her way.
It could be really confusing and overwhelming. He'd have to deal with all the societal expectations and differences that come with being a girl.
One possible plotline could be that Sakura leaves Konoha due to a personal quest for self - discovery. She might feel that she has outgrown the village or that there are things she can't achieve while staying there. For example, she could be in search of a new medical ninjutsu technique that can only be found in a far - off land. Along the way, Sasuke might cross her path, and they could either have a moment of reconciliation or further conflict depending on their respective states of mind.
Iruka sensei is almost certain to be in it. He has always been important in Naruto's life. Also, Sakura might be there. She could be one of the first to welcome Naruto or perhaps she might initially be a bit cold because of her past feelings for Sasuke. Other characters like Kakashi sensei could also make an appearance, guiding Naruto in his new life in Konoha.
It could be that Naruto has a vision of a different kind of life or place where he can truly be at peace. He might meet someone from another village or group who shows him an alternative way of living that is more appealing than staying in Konoha. And so, he gives up on Konoha to pursue this new path.
Natsume would probably be one of the main characters to appear. Their relationship was quite significant when they were younger, and it could continue to evolve as they grow up. Hotaru might also be there, as she was Mikan's good friend. And there could be new characters introduced, like colleagues if the fanfiction focuses on her career, or new friends she makes in her adult life.
Obviously Sakura herself is the most important character. Naruto and Sasuke would also be important as they are her friends and comrades. Kakashi could also play a role, maybe as a mentor or someone who gives her advice on how to readjust to Konoha life.
They might leave to seek new forms of power or knowledge. There could be things outside of Konoha that they believe will help them become better at their ninja skills. For instance, they might have heard of a special dojo or a hidden scroll in another land that could enhance their abilities.
One possible plotline could be that they leave to seek a new form of power. Maybe they've discovered a threat that the Hidden Leaf isn't aware of, and they believe they can find a solution outside. Another could be that they're on a journey of self - discovery. Sakura has always been in Sasuke's shadow to some extent, and this could be her chance to truly find herself while being with him. Also, perhaps they leave due to some political unrest in Konoha that they don't want to be a part of.
Since it's a fanfiction about sakura and memory loss, perhaps the main character is someone who has lost their memories of a particular sakura - filled place or event. It could be a person who was once part of a sakura - themed community or had a personal experience with sakura that was so important that its loss has left a void. There might also be a secondary character, like a friend or a guide, who helps the main character in their journey to regain the memories.