Maybe it's an organization that believes the dragon's blessing is an abomination to the wizarding world's natural order. They see Harry as a threat and will stop at nothing to eliminate him and the power he has received. They could be a secret group within the Ministry of Magic that has its own radical ideas about magic and purity.
There is a possibility that the dragon itself turns out to be the main antagonist. After giving the blessing, it might have some ulterior motives. For example, it could be using Harry as a pawn in a larger scheme to take over the wizarding world. The dragon may have given the blessing not out of kindness but as a way to manipulate Harry into doing its bidding.
There could be a group of pure - blood wizards who believe that dragons are beneath them and that Harry is tainting the wizarding world by associating with them. They would try to stop Harry from his dragon - related activities, and they might use underhanded tactics like casting spells on him or trying to get him expelled from Hogwarts.
Maybe a group of dark wizards who are jealous of the power of the dragon knights. They form an alliance to destroy the dragon knights and anyone associated with them, making Harry and his newfound friends their main targets.
It could be Voldemort still. Even with Harry having the power of a dragon god, Voldemort would be a major threat. He might be envious of Harry's new power and try to steal it for himself.
In some cases, it could be a jealous Hogwarts student. This student might be envious of Harry's special bond with the dragon. They could try to undermine Harry and the dragon's relationship, maybe by spreading false rumors or trying to get the dragon in trouble with the school authorities. This student could be working with some dark forces indirectly, as their envy makes them vulnerable to being influenced by the wrong side.
Perhaps a group of anti - dragon fanatics within the wizarding world could be the main antagonists. They see the dragon as a dangerous and uncontrollable creature and will do anything to get rid of it, even if it means going against Harry.
It could be another wizard who wants to use the dragon for evil purposes. This wizard might try to stop Harry from taming the dragon so that he can have it for himself.
It could be a dark wizard who wants to control the holy dragon for his own evil purposes. He might see the dragon as a weapon to take over the wizarding world.
One possible plot could be that Harry discovers a dragon in the Forbidden Forest. The dragon, for some reason, decides to bestow a special blessing on Harry. This blessing might give him enhanced magical abilities, like being able to control fire in a way no other wizard can. It could also lead to a new adventure where he has to face dark wizards who are after this new power of his.
There could be a group of ninja from a hidden village that has always been envious of Konoha's power. When they hear about Naruto being blessed by Amaterasu, they see it as an opportunity to weaken Konoha. So, they send their best assassins to either kill Naruto or steal his power, making this group the main antagonists in the fanfiction.
Perhaps a long - lost relative of the Potter family who feels they were unjustly excluded from inheriting the manor. This relative could be jealous of Harry's status and the wealth associated with the manor. They might use dark magic to try and claim what they think is rightfully theirs, leading to a battle of magic and loyalty within the Potter family and among Harry's friends.