Perhaps in a dark, alternate universe version of the story. The world has gone mad, and Sakura is seen as a threat for some reason. The authorities or a powerful organization target her. They set up elaborate traps and ambushes. Sakura tries to fight back but is ultimately overpowered and killed. It could also explore how her friends react to her death in this different setting.
One possible storyline could be a battle scenario where the enemy is far too powerful for Sakura. Maybe she's outnumbered and despite her best efforts in combat and using her medical ninjutsu to heal herself and allies, she eventually succumbs to the attacks. Another could be a betrayal within her own group, where someone she trusts stabs her in the back, literally. This would add a lot of drama and angst to the story.
In a fanfiction, Sakura could be killed due to a sacrifice. For example, to save her village or her friends. She might put herself in harm's way to stop a powerful jutsu or a deadly enemy attack. Her death would then be a heroic one, and the story could focus on how her sacrifice inspired others or changed the course of events in the story world.
In a fanfiction, it could be that a scientific experiment gone wrong in Gotham creates a mutant - like creature that has super strength and intelligence. This creature targets Batman as it sees him as a threat to its new - found power in the city. After a long and brutal battle, the creature overcomes Batman and kills him.
Perhaps Sakura is in the hospital because she's been overworking herself in her medical ninja duties. In the fanfiction, she could meet a young patient who has a rare disease. Sakura then devotes herself to finding a cure for this patient, all while dealing with her own health issues. This would show her selfless and determined nature.
In this fanfiction, perhaps Amy is in a difficult situation when she gets pregnant. For example, she could be in the middle of pursuing a big career opportunity. The story might revolve around her decision - whether to keep the baby and put her career on hold or to choose her career over the pregnancy. There would be a lot of internal struggle and emotional turmoil.
One possible storyline could be that Naruto discovers he has long - lost relatives. Maybe his father had a secret sibling and Naruto stumbles upon this family during a mission in a far - off village. This new family could be very different from the friends he grew up with in Konoha, introducing him to new ways of life and ninja techniques.
One possible storyline could be that Shikadai is on a mission and gets caught in an unexpected ambush by a group of powerful enemies. He might be outnumbered and sustain injuries while trying to fight them off and protect his comrades. Another could be that he's involved in a training accident that goes horribly wrong, like a jutsu backfiring on him and causing him physical harm.
Another storyline might involve Deku having to face some sort of villain threat right before the wedding. He has to balance protecting his loved ones and ensuring the wedding goes on as planned. Maybe a new villain emerges who wants to disrupt the harmony of the event. But with the help of his friends and his own heroic skills, Deku manages to defeat the villain and still have a wonderful wedding.
Perhaps Stiles is killed as a sacrifice in a dark ritual. His death could be part of a much larger conspiracy. His friends might start seeing strange visions of him after his death, which they initially think are just their minds playing tricks on them, but later realize are actually Stiles trying to communicate from the afterlife to help them stop the forces behind his death.
In a fanfiction, Elsa might be killed as a sacrifice. There could be an ancient prophecy that states that in order to save Arendelle from an eternal winter that is a result of an even more ancient curse, Elsa, as the most powerful magic - wielder, has to give up her life. She accepts this fate willingly, and as she dies, her last act is to break the curse, leaving her people in a state of shock and mourning.
One possible storyline could be that Sakura leaves the village to seek advanced medical training in a far - off land. She might face challenges in a new environment, meet new allies and enemies, and come back to the village with enhanced skills to better serve her people.
One possible storyline could be that Sakura is injured during a battle. Maybe she's protecting someone and takes a hit that leaves her seriously wounded. Her friends then have to find a way to heal her while also dealing with the threat that caused the injury.