If there's a love interest in the story, they might have a mix of reactions. At first, they could be amused by Xion's drunken antics. But as she gets more and more out of control, they would become worried and step in to take care of her. Later, when she's sober, there could be some tender moments between them as they talk about what happened.
Her best friend might be very concerned and protective. They would try to keep her from doing anything too crazy while drunk. For example, if she tries to walk into traffic, they'd stop her.
Some of the more uptight characters could be scandalized by Xion getting drunk. They might lecture her when she's sober again about proper behavior. But others who are more laid - back could just laugh it off and say it was a wild night.
Arthur might be initially shocked and confused. He's used to Merlin being in control. But then he might find it quite hilarious and start teasing Merlin about it.
In this fanfiction, Xion's drunk state could lead to her revealing some deep - seated secrets. For example, she might disclose her true feelings about a certain person or a past event. Her friends are shocked but also more understanding of her after this. They help her through the aftermath of getting drunk and the emotional turmoil that comes with revealing her secrets.
If Rex were with her, he would be concerned. He'd watch over her closely, making sure no one took advantage of her in her drunken state. He might also try to find a way to help her sober up, like getting her some water or finding a quiet place for her to rest. Meanwhile, other characters who don't know her well might misjudge her and think she's just a reckless individual, but those who are her true friends would understand that it was an accidental situation and support her through it.
The characters' reactions would be quite complex. Adrien would first be in denial, not wanting to believe that Plagg could be akumatized. Then he would feel a mixture of anger and sadness. He might blame himself for not being able to protect Plagg. Marinette as Ladybug would be focused on the bigger picture. She would try to assess the situation quickly and figure out if there are any weaknesses in the akumatized Plagg's powers. Tikki would be worried too, as she has a relationship with Plagg. She might offer some advice to Ladybug based on her knowledge of kwamis.
Naruto would be devastated. He and Sakura have a long - standing relationship, and her death would hit him hard. He might go into a rage, seeking revenge on whoever was responsible. Sasuke, too, would be affected. Even though their relationship was complex, Sakura was still an important part of his life. He could become more withdrawn or more determined to change the world that allowed such a thing to happen.
Her friends could be really surprised. They're used to a more composed Daria. They might first be concerned because she's not wearing her glasses and then realize she's drunk. Some might try to take care of her, while others could be a bit more amused at seeing this different side of her.
Li Shang would probably be very concerned. He might blame himself for not protecting her better. He would immediately call for the best medical help available and stay by her side until she recovers.
The Twilight characters would be quite shocked. Vampires like Edward might be very suspicious of Hermione's new status as an imprinted character. Werewolves like Jacob would have a different reaction. Since imprinting is a big part of their culture, they might be more accepting but also cautious as Hermione is an outsider from a different fictional universe. They would need to figure out how to incorporate her into their pack or deal with her in some way.
Harry would probably be in a state of shock and disbelief at first. He'd be filled with a mix of fear, confusion and anger. Voldemort might be initially dismissive or see it as an opportunity to further his own dark plans. Hermione would be practical, trying to find solutions in books and magic. Ron would be more likely to be openly disgusted at first but might come around to support Harry as a friend.
Yuki would likely be very concerned. He has a soft spot for Tohru and would probably rush to her side, trying to find a way to help. He might even blame himself if he thinks he could have prevented it. Kyo, on the other hand, would initially be angry, but that's just his way of showing worry. He would be more hands - on in getting her the help she needs.