Sasuke might be more understanding. Given his own experiences of leaving Konoha, he could respect Naruto's decision. However, he might also secretly plan to keep an eye on Naruto from afar to make sure he is safe.
The Hokage at the time would be in a difficult position. On one hand, they would want to keep Naruto in Konoha as he is an important asset. On the other hand, they would have to respect Naruto's wishes if they are based on valid concerns for his and his child's safety. They might send some trusted ninja to follow Naruto secretly.
Sakura would probably be very worried. She has always cared about Naruto deep down, so she might be constantly trying to find a way to bring him back. Kakashi, on the other hand, would likely understand Naruto's reasons to some extent. He might be sad but also respect Naruto's decision. As for Sasuke, if he is in the village at the time, he could be conflicted. He and Naruto have a complex relationship, and Naruto's leaving might make him realize how much Naruto actually means to him.
Naruto would be devastated. He has always considered Sakura as a dear friend and teammate. He would probably try to convince her to come back at first. If that fails, he might see it as his mission to bring her back by force if necessary, believing that she has been led astray. Sasuke, on the other hand, might have a more complex reaction. He has his own issues with Konoha, so he might understand Sakura's desire to leave on some level, but he would also be suspicious of her motives for joining Akatsuki.
For Naruto, it would be a big shock. He's always seen Sakura as an important part of the team. He would probably feel guilty, thinking he might have done something wrong. Sasuke might be more reserved in his reaction, but deep down, he would also feel the loss. Kakashi would be worried about her safety. The other ninja in Konoha might start to question the unity of the village if someone like Sakura, who was so well - known, left. And the young ninja who looked up to Sakura would be disappointed and might even lose some motivation in their training.
Sasuke might initially be shocked. He has always seen Sakura as someone connected to Konoha, so her leaving would be unexpected. He could be concerned about her safety, especially if she leaves without proper preparation or protection.
The kids in Konoha like Naruto would probably be very excited. They love new and different things, and Harry with his magic would be really cool to them.
The younger generation, like Sakura and the other ninja trainees, would be terrified. Some might be angry at Naruto and Kushina, while others might be more confused. Sakura, in particular, might feel betrayed as Naruto was her friend and teammate. But at the same time, she might wonder if there was a good reason behind their actions and struggle with her loyalty to Konoha and her feelings for Naruto.
Konoha's power structure could be affected. Naruto is one of the strongest shinobi in the village. Without him, the village might be more vulnerable to attacks from other villages or threats. They would need to quickly find ways to fill the gap in their defenses.
Naruto would probably be conflicted. On one hand, he has a deep love for Konoha, his home. But on the other hand, he might have been hurt by the past events that led to his departure. He could initially be hesitant, but eventually be swayed by the thought of seeing his friends again.
The older generation, like Tsunade, would be horrified. They've seen Konoha through many hardships and would not want to see it destroyed. They would likely mobilize all available forces to stop Naruto and the Kyuubi. Meanwhile, Naruto's friends like Shikamaru and Choji would be in shock. They've always known Naruto as a kind - hearted and loyal friend, and this sudden turn would be very difficult for them to accept. They might initially be in denial and then try to find a way to stop Naruto without harming him.
Konoha would initially be in shock. Naruto is a hero to many in the village, and his sudden departure with Itachi, who was once considered a traitor, would cause a lot of unrest. The villagers might start to question the leadership of the village, wondering why Naruto left and if there was something they could have done to prevent it.