Maybe some sort of combined form of Orochimaru and a powerful Hollow. Orochimaru is always after power and knowledge, and in this fanfiction, he could have somehow made his way into the Bleach world during Naruto's exile. The combined entity would be extremely dangerous, having both Orochimaru's cunning and the Hollow's brute strength.
It could be a power - hungry shinobi from another village. This shinobi sees Naruto's exile as an opportunity to gain more power and influence in the ninja world. He might try to hunt Naruto down to prove his own strength or to steal Naruto's secrets.
Maybe the main antagonist is an outside force that has influenced the Fairy Tail guild to exile Naruto. For example, a dark guild could spread false rumors about Naruto, making the Fairy Tail members believe that he is a danger to them. This way, they can get Naruto out of the picture and then plan an attack on the Fairy Tail guild without having to deal with Naruto's power.
Perhaps an ancient and dark deity who has been awakened due to some event related to Percy's exile. This deity wants to bring chaos to the world of gods and demigods, and Percy, even in exile, is the only one who can stop it. The deity would use all kinds of dark magic and minions to oppose Percy and his friends.
Maybe a rogue demigod who blames Percy for something and wants to make his exile permanent. This demigod could have some dark powers or be in league with some evil forces. They would constantly try to thwart Percy's attempts to return or find a way to clear his name.
It could be a new dark wizard who has risen to power. This wizard might see Harry as a threat to his plans, so he manipulates the situation to get Harry exiled.
A possible main antagonist could be Aizen from 'Bleach' who somehow gains the ability to control the powers from Lucy's world as well. He could use this newfound power to try and take over both the Bleach universe and Lucy's world. His cunning and powerful abilities would make him a formidable foe for Lucy and the Bleach characters to face.
A dark force that has the ability to influence the minds of Gryffindor members. This could be a powerful and ancient magic or a new form of dark magic. It turns the house against Harry without them fully realizing it, making the collective Gryffindor house, under this influence, seem like the antagonist.
Aizen could be a great main antagonist. He's extremely intelligent and powerful in the Bleach universe. He might see the Miraculous as a means to further his own goals, whether it's to gain more power or to create more chaos. His manipulative nature would make him a formidable foe against Ladybug and Ichigo.
Aizen could still be the main antagonist. Even if Ichigo travels back in time, Aizen's long - term plans might be already in motion. Ichigo would have to find a way to expose and stop Aizen earlier than in the original timeline.
In Naruto fanfiction, Sasuke can often be portrayed as an antagonist in some 'what - if' scenarios. For example, if he fully embraced the power of the Curse Mark and turned against Konoha completely. In Bleach fanfiction, Aizen is a popular antagonist to explore further. His complex plans and manipulation can be delved into more deeply, like exploring his motives before he even started his grand scheme.