In a more fantasy - based romance novel, the world could be populated with creatures that are part human and part animal due to their unique DNA. A human character might fall in love with one of these beings. The differences in their DNA - influenced characteristics, such as different communication styles (maybe a character with bird - like DNA can sing in a special way) or physical abilities, create challenges and opportunities for the romance to develop. There could be a struggle to understand and accept each other's natures, which is at the heart of many great love stories.
Animal DNA can be part of a family curse or blessing in a romance novel. For instance, a family might have a bit of wolf DNA passed down generations. A member of this family falls in love with someone outside the family. The animal DNA and the secrets associated with it add intrigue and drama to the love story. The other character has to learn to accept the strange behaviors that come with the wolf DNA, like a heightened sense of smell or protectiveness during a full moon.