Another plot twist might be that the relationship between Hermione and someone unexpected, like a Slytherin student, changes drastically. In the fanfic, they could start off as enemies but then find out they have a common goal related to the secrets of the Half - Blood Prince. This could lead to an unlikely alliance and a whole new set of adventures for Hermione.
Perhaps the biggest plot twist could be that the identity of the Half - Blood Prince is not what everyone thought it was in the fanfic. It could turn out to be someone very close to Hermione, like a teacher she trusts or even a relative. This revelation would completely change her perspective on the whole situation and send her on a journey to uncover the real motives and history of this person.
Well, Harry Potter is likely to be one of the main characters. He's always been an important part of Hermione's life in the original series, and in this fanfic, he might play a crucial role in the events related to the Half - Blood Prince. Maybe he and Hermione are on a joint mission to uncover the secrets of the Half - Blood Prince.
One interesting plot twist could be Hermione discovering a hidden power within herself related to the Deathly Hallows. Maybe she finds out that she has a special connection to the Elder Wand that no one suspected before.
One interesting plot twist could be that Hermione discovers a hidden spell within the Goblet of Fire that no one else knew about. This spell could change the nature of the Triwizard Tournament in unexpected ways.
One interesting plot twist could be that Hermione discovers she's the Heir of Stone not through traditional means but during a dangerous encounter with a dark wizard. The wizard tries to use her for some evil purpose related to the power of the Stone, but she manages to turn the tables on him.
One interesting plot twist could be that Hermione discovers a hidden power within herself that has a connection to the Chamber of Secrets. Maybe she can communicate with the basilisk in a unique way, which completely changes how she approaches the mystery.
One plot idea could be exploring their relationship in more depth during the events of Half - Blood Prince. Maybe Ron starts to notice little things about Hermione that he hadn't before, like how she always has the right answer in class. Another could be a story where they have to work together on a secret mission related to the Half - Blood Prince's potions book. They might argue at first but then realize how much they rely on each other.
In certain fanfictions, a plot twist could be that the Half - Blood Prince was not a single person but a group of wizards working together. They had been leaving the notes in the potions book for a greater purpose. Another interesting plot twist might be that the Half - Blood Prince was actually an animagus and could transform into a creature that had a special connection to Voldemort's Horcruxes. This would add a whole new layer to the story. Also, there could be a plot twist where the relationship between Harry and Snape is completely different from the start. Snape is actually trying to protect Harry in a much more obvious way, but Harry misinterprets his actions because of the false reputation Snape has in the fanfiction world.
In some fanfictions, a great plot twist is that Harry himself has some hidden powers that are awakened during his sixth year. For example, he might gain the ability to communicate with magical creatures in a much deeper way. This could lead him to discover secrets about Hogwarts that even Dumbledore didn't know. And perhaps the relationship between the Half - Blood Prince and a long - lost relative of Harry's is revealed, which throws a whole new light on his family history and his role in the wizarding world.
One interesting plotline could be Hermione's discovery of new spells related to the Half - Blood Prince's notes that she uses to outwit the Death Eaters. For example, she might find a unique defensive spell that saves her friends during a battle.
One interesting plot twist could be that Hermione is secretly entered into the Triwizard Tournament not by the Goblet, but by a dark wizard who wants to use her as a pawn. This would put her in a very dangerous situation right from the start.