In some fanfiction, Harry leaves to seek more powerful magic. He realizes that the magic in Britain is somewhat limited in the fight against Voldemort. So he travels to other places, like ancient magic - rich regions in Asia or Africa, to find a way to defeat Voldemort. He hopes that by leaving, he can gain the upper hand in the battle.
One possible reason could be to seek new opportunities. In fanfiction, the States might be depicted as a place full of exciting prospects in various fields like magic (if it's a Harry Potter - related fanfic) or just in general life. For example, he could be interested in exploring different magical cultures there.
One interesting fanfic could be 'Away from the Darkness'. In this story, Harry leaves Britain secretly and travels to a far - off land where he discovers new magic that he can use against Voldemort. It has great character development and an exciting plot.
One reason could be a falling - out with his friends in Gryffindor. Maybe there was a misunderstanding that grew so large that he felt he couldn't stay. Another possibility is that he might be lured away by some mysterious force or character who convinces him that Gryffindor is no longer the right place for him. For example, if a new group claims to have a better way to fight Voldemort and they are from a different 'house' in this fanfiction concept.
Another reason could be a misunderstanding. Maybe he overhears something Harry and Hermione say and misinterprets it as them not wanting him around anymore. So, in a fit of anger and hurt, he leaves. This can lead to a lot of angst and drama in the fanfiction as the other characters then have to figure out how to get him back.
One possible reason could be a major disagreement with the Gryffindor house leadership or some of the students. Maybe he feels that they are not living up to the values he thought they held. Another reason might be that he discovers some dark secret within Gryffindor that makes him uncomfortable and he decides to leave.
Maybe he's tired of the spotlight in England. In some fanfictions, he could be seeking a new start away from the prying eyes and the constant media attention that comes with being in England.
One reason could be a prophecy misinterpretation. Voldemort might initially think that Harry is key to his success in a different way than he originally thought, and so he saves him to figure out this new angle. For example, if there was a prophecy about a 'chosen one' and Voldemort realizes he needs Harry alive to fulfill some part of it that benefits him.
Perhaps in the fanfiction, Harry Potter runs away from Britain because he is disillusioned with the way the Ministry of Magic operates. There could have been a major event where the Ministry fails him or betrays his trust. Also, he may be seeking a place where he can explore his magic without the constraints and expectations that come with being 'The Boy Who Lived' in Britain.
In the fanfiction world, it could be a prophecy. There might be a prophecy that says Harry's presence in Ginny's life will bring great harm to her or the wizarding world. So, for the greater good, Harry leaves. He believes that by sacrificing his relationship with Ginny, he can save her and everyone else. It's a very noble but also a very heart - breaking decision.
In some fanfictions, Harry might leave his family because of a prophecy or a special mission. He might feel that he has to go it alone in order to fulfill this prophecy or complete the mission successfully. His family might not understand or be able to support him in this, so he decides to leave. Also, there could be jealousy or resentment within the family that makes the environment unbearable for Harry.