There could be a situation where a Transformer's technology gets mixed with Oscorp's experiments. This creates a new kind of threat that Spider - Man has to face. The Transformers get involved because it's their technology that's been misused. Together, they figure out a way to reverse the effects and defeat the new hybrid - like villains.
One idea could be a crossover with the X - Men. Spider - Man could team up with Wolverine. Their different fighting styles would make for some amazing action scenes. Wolverine's brute strength and healing factor combined with Spider - Man's agility and web - slinging abilities would be a great combination.
One idea could be that during a mission crossover, Spider - Man gets injured while trying to protect a civilian from an unexpected attack by a powerful enemy. Maybe he takes a hit meant for an Avenger and his suit's technology malfunctions, leaving him vulnerable.
In a Harry Potter and Spider - Man crossover fanfiction, perhaps the Venom symbiote attaches itself to a Hogwarts student. Spider - Man then has to travel to the wizarding world to stop the now - corrupted student from causing chaos. Along the way, he discovers that the magic in the wizarding world can both help and hinder his attempts to subdue the symbiote - controlled student. Harry and his friends might initially be suspicious of Spider - Man but then realize they need his unique skills.
In a Transformers and Bumblebee crossover fanfiction, Bumblebee could lose his memory and the other Transformers have to help him regain it while also protecting him from the Decepticons who see this as an opportunity to take him out. They go on a journey through different planets and encounter various strange species along the way.
If Optimus Prime and Spider - Man were to interact, Optimus would likely be a source of wisdom and guidance for Spider - Man. He could offer his perspective on leadership and protecting the innocent. Spider - Man, in turn, could show Optimus how to be more agile and adaptable in the urban environment of New York.
Well, they could be in a situation where Iron Man's reputation is on the line due to some false accusations. Spider - Man believes in his innocence and decides to help him clear his name. Together, they start investigating who is behind the smear campaign. Along the way, they encounter a powerful enemy who is trying to keep them from finding the truth. This would involve a lot of detective work from Spider - Man and high - tech solutions from Iron Man.
One idea could be that Anastasia is a long - lost Cybertronian in human form. The Autobots discover her true identity while on Earth and have to protect her from the Decepticons who want to use her unique connection to both Earth and Cybertron for their evil plans.
One idea could be a scenario where the Autobots from Transformers Prime team up with Iron Man to fight a common enemy like an evil tech - based villain. They could combine their technological prowess. For example, Iron Man could share his advanced weaponry designs with the Autobots, and in return, the Autobots could teach Iron Man about their energy sources.
One idea could be a crossover with the X - Men. Spider - Man could find himself in the middle of a battle between the X - Men and some common enemy, like the Sinister Six. He'd have to figure out how to work with mutants, which is a whole new experience for him. Another idea is a crossover with the Fantastic Four. Maybe Spider - Man gets caught up in one of their space - related adventures. Reed Richards could be fascinated by his web - shooters and try to study them, while Spider - Man would be in awe of their super - scientific gadgets.
Another interesting plot could be that a mad scientist creates a device that can separate Venom from his host. However, the separation goes wrong and the symbiote energy starts to spread across the city, infecting people. Spider - Man and Venom must work together to find a way to contain the energy and save the city.