In a crossover, it could be argued that Saitama from One Punch Man (since he is often joked about in crossovers) would be the most powerful. Just kidding! Seriously though, Vegito, the fused form of Goku and Vegeta, has an insane amount of power. He combines the strength and skills of two of the most powerful Z - fighters. In the Marvel universe, characters like the Beyonder have near - omnipotent power. But Vegito's fighting spirit and his ability to constantly adapt and grow in battle could make him a top candidate for the most powerful character in a crossover. His Saiyan instincts and power - up abilities could give him an edge over some of the Marvel powerhouses.
It's hard to say for sure, but Goku would be a very strong contender. His ability to keep increasing his power level through training and reaching new forms like Super Saiyan God and Ultra Instinct makes him extremely powerful. However, characters like Franklin Richards in the Marvel universe have reality - warping powers that could also be very hard to defeat. But if Goku were to fully master Ultra Instinct and combine it with the power of the Dragon Balls, he could potentially be the most powerful.