In terms of their relationship with their families, if they have any remaining family members. Naruto's family, like Jiraiya (if he's still alive in this fanfiction) could be overjoyed and offer all kinds of support. Sasuke's family, perhaps Itachi (again, if alive) might have a more complex reaction, being both proud and worried about the future of the Uchiha bloodline with this new development.
Well, their relationship with Sakura could become more strained. Since they left, she might feel abandoned and angry at them at first. But later, she could also come to understand their reasons. With Kakashi, he might be disappointed in them for leaving, but also secretly hope they find their own path. As for their enemies outside the village, they might start to see Naruto and Sasuke as more of a threat since they are no longer bound by the village's rules.
Well, fem Sasuke might be more in touch with her emotions compared to the original Sasuke. She could show vulnerability more easily. Naruto, on the other hand, might become more protective. For example, he might be quicker to jump into a fight if fem Sasuke is threatened.
Well, their relationship with Kakashi would be different. Instead of just being their teacher, he might see them more as a family unit. He would have to deal with their sibling dynamics, like Naruto and Sasuke's competitiveness and Sakura trying to keep the peace between them.
If the roles were reversed, Sasuke would be the one that Hinata might have a secret crush on. Since he would be the more outgoing and friendly one. And Sasuke would probably be more involved with the village kids, mentoring them like Naruto did. Naruto, as Sasuke, would have a more strained relationship with the Hokage. The Hokage might be constantly worried about Naruto's motives and actions. His relationship with Jiraiya would also change. Jiraiya might be more cautious around Naruto, instead of the carefree mentorship they had in the original story.
With Kakashi, Kakashi would be extremely cautious around Naruto. He would be constantly on guard, worried that Naruto might inherit some of Fem Madara's more dangerous tendencies. Naruto would have to prove his loyalty and good intentions to Kakashi over time.
Well, with Kakashi, he might be more cautious in how he trains Sasuke. As a girl, Kakashi might have to consider different aspects of training, like physical limitations that might come with the female form. His relationship with his clan members, if they were still around, could also be different. They might have different expectations of a female Sasuke. And when it comes to the other male ninja in the village, some might be attracted to him, which would create some awkward or interesting situations.
Her relationship with Sasuke could be really different. Since she can't express herself verbally, Sasuke might initially misunderstand her. But as he gets to know her better, he realizes that her actions speak louder. For example, when she saves him from danger, he starts to see her in a new light. With Sakura, they might develop a more sisterly bond as Sakura tries to help Fem Naruto communicate in different ways.
During the pregnancy, their relationship could deepen in many ways. Sasuke might open up more about his feelings. He's always been a bit of an enigma, but with a baby on the way, he'd have to be more communicative. Fem Naruto would also start to see a softer side of Sasuke. They'd have to work together more closely, like when it comes to preparing for the baby's arrival, which would strengthen their bond.
With their friends, they would be more like mentors. For instance, they might be training the younger generation more strictly. Naruto would still be the fun - loving guy but also be more authoritative. Sasuke would be more approachable than before, sharing his knowledge about the Sharingan and his combat experiences.
It would likely become more cooperative. They'd have to communicate more often to take care of the pregnancy - related matters.