Another possibility is a group of dark wizards who are jealous of Harry's unique upbringing by Amy and Rory. They might see Harry as a threat to their traditional ways of using magic and try to get rid of him. This would lead to a series of battles and conflicts, with Amy and Rory using their own resources and allies to protect Harry.
Maybe it could be an evil wizard from the Doctor Who universe who has somehow made his way into the Harry Potter world. This wizard could have powers that are different from what Harry is used to, and it would be a real challenge for Amy, Rory, and Harry to defeat him. They would have to combine their magic and their knowledge of different universes to stop this new threat.
It could be Voldemort, of course. He would be a formidable foe, and it would be interesting to see how Amy and Rory's knowledge and skills would help Harry in the fight against him.
Well, they might raise Harry in a world where the Doctor Who universe and the Harry Potter universe collide. They could introduce Harry to all kinds of alien species and magical - technological hybrids. For example, they could show him a broomstick that can also fly through time and space. This would make for a really exciting fanfic as it combines two very popular universes.
The main antagonist could be a powerful necromancer who combines the dark arts of Skyrim with some elements of Voldemort - like magic. He could be raising an army of the undead and causing chaos across Skyrim, which Harry has to stop.
It could be a new dark wizard who has a vendetta against Harry. This wizard might use a spell to stop Harry from eating, thinking it will weaken him before a final showdown. He could be someone who was once a follower of Voldemort and now wants to take his place and prove himself by getting rid of Harry.
Maybe an ancient evil spirit that was once bound but is now trying to break free by using the summoner as a conduit. This spirit could be manipulating events from the shadows, causing chaos in the wizarding world to draw the summoner out.
Perhaps an ancient spirit that has been awakened by the imbalance in the life - death cycle due to Harry becoming the Master of Death. This spirit sees Harry as the cause of the chaos and tries to destroy him to restore the balance in a way that is harmful to the wizarding world.
In an alternate dimension, the main antagonist could be a dark entity that has emerged from the very fabric of the dementions themselves. This entity could be using the Dementors as its minions, controlling them to do its bidding. It would be a powerful and mysterious foe, and Harry would have to discover its true nature and weaknesses in order to defeat it.
There is also a possibility that the main antagonist is the Goblet itself if it has been corrupted by some ancient dark magic. It could be summoning Harry not for a normal Tournament but to sacrifice him or use his power for some evil purpose, making the Goblet the force that Harry has to fight against.
Maybe the demon's soul itself could be the main antagonist in a way. It has its own will and desires, which are mainly to spread chaos and destruction. It could possess other characters in the story and make them act against Harry. For instance, it might possess a Hogwarts professor who then tries to undermine Harry's efforts to stop it. The demon's soul's ability to manipulate and corrupt would make it a very dangerous and menacing antagonist.
It could be a rogue Death Eater who wants to take over Voldemort's position and sees Harry and Bellatrix's new - found alliance as a threat. For example, a Death Eater who was always jealous of Bellatrix's closeness to Voldemort.
It could be a new dark wizard who has somehow tapped into the power of both the wizarding world and the Narnian magic in a negative way. This wizard might want to rule both realms and is using dark magic from both to achieve his goals.