Naruto and Alex Mercer are often popularly paired. Naruto's positive attitude and strong will, combined with Mercer's raw power, make for an interesting dynamic. They can learn a lot from each other, like Naruto can teach Mercer about the importance of friendship, while Mercer can show Naruto some new ways to use power.
Sasuke and Mercer are also a common pairing. Sasuke's thirst for power and his brooding nature can contrast well with Mercer's own power - hungry and somewhat aloof personality. Their interactions can range from being rivals to begrudging allies in different fanfiction stories.
Another popular pairing could be Hinata and one of the female characters from Prototype (if there are any significant ones). Hinata's shy yet determined nature can create an interesting relationship with a more assertive Prototype character. They might bond over their shared experiences of trying to prove themselves in their respective worlds.