Naruto himself is obviously a must - include. Hinata is also very popular as his wife. Their kids, like Boruto and Himawari, are often featured. Also, characters like Sasuke can be included as Naruto's long - time friend who might interact with his family.
Naruto, Hinata, and their children are the main ones. However, other characters like Shikamaru, who is Naruto's friend and advisor, can add an interesting dynamic. Also, Sakura, as another important character from Naruto's past, could be included. Maybe she helps out Hinata when one of the kids is sick or something, showing the friendship between the two women in Naruto's family - centered world.