Snape might initially be taken aback. He's not used to students standing up to him so forcefully. He could glare at Hermione with his cold, dark eyes, trying to intimidate her into silence.
In some fanfictions, Snape might actually respect Hermione a bit more for her courage. He might not show it outwardly, but internally he might think that she has the kind of spunk that he admires, even if he doesn't like being yelled at. So, he could give a curt response and then walk away, deep in thought.
He might be initially shocked. Snape is used to students being intimidated by him, so Hermione's outburst could catch him off - guard. He may glare at her silently for a moment, trying to regain his composure.
Snape might initially be taken aback. He's used to students being intimidated by him, so Hermione's outburst could shock him into momentary silence. Then he might retaliate with his usual sarcasm, trying to put her in her place.
In some fanfictions, Snape might see this as an opportunity for his own growth. He might accept the apology gracefully, realizing that holding onto grudges isn't helping him. This could lead to a new relationship between them, where they start to understand and respect each other, or at least tolerate each other's presence.
On the other hand, he could feel ashamed. If he realizes that he has truly made a mistake, seeing his father so angry and disappointed could make him feel bad about himself. He might lower his head and not say anything, with a look of guilt on his face.
Snape might initially be shocked. He's not one to show much emotion openly, but internally he could be very disturbed. He might start investigating what happened to Hermione immediately, using his skills in potions and magic to try and find a cure or at least understand the cause.
She might initially be shocked and scared. But then she would start to think rationally and try to find a way to outwit Snape. For example, she could start to gather evidence against Snape's own wrongdoings, if there are any, so that she can turn the tables on him.
He could also be a bit sarcastic in his response. Snape has a sharp tongue, so he might say something like 'Miss Granger, what makes you think I have the time or inclination to help you?' But as Hermione explains her situation, he might gradually soften, realizing the seriousness of the matter. Maybe he starts to see a bit of himself in Hermione's thirst for knowledge.
He may show a rare moment of kindness. Given his own past traumas and experiences, he might empathize with Hermione on some level. He could offer her some words of wisdom or even some form of magical assistance to help her get better.
He might be initially startled. Snape is used to seeing Hermione as a strong - willed and confident student. So seeing her crying could catch him off - guard. But then he might quickly put on his usual cold facade and ask her curtly what's wrong.
Another reaction could be that Sakura becomes more determined. His yelling could fuel her desire to prove herself to Sasuke, whether it's in terms of her strength, her loyalty, or her understanding of him. So instead of being deterred, she uses it as motivation to grow and change in the eyes of Sasuke.