A really interesting plot twist could be that the blind woman's love is part of a prophecy. In the fanfiction world, prophecies are often used to drive the story. So, her love for Medusa could be the key to saving a whole kingdom or something huge. Maybe the two of them have to go on a journey together because of this prophecy, and along the way, they face all kinds of challenges that test their love and their resolve.
The plot could involve Medusa finding the blind baby. Maybe she uses her powers in a unique way to protect the baby from other threats in the mythological world.
A plot twist could be that Medusa is actually an undercover agent sent to the Naruto world to steal secrets, but she falls in love with Naruto instead. This would create a conflict between her original mission and her new - found feelings.
One way to develop their relationship is through mutual understanding. The blind woman, not being able to see Medusa's terrifying form, can see her true self. Medusa, in turn, can appreciate the blind woman's lack of fear. They could start doing things for each other, like Medusa protecting the blind woman from threats, and the blind woman helping Medusa to see the good in herself. As time passes, their relationship can grow from a simple attraction to a deep, loving bond.
Well, it could be that when Percy looks at Medusa, their minds get swapped. Percy then has to figure out how to use Medusa's powers and body to his advantage while also trying not to get killed by the heroes who are coming after 'Medusa' (who is really Percy in her body). And Medusa, in Percy's body, has to deal with his life, like his relationships with Annabeth and his friends at Camp Half - Blood, which could lead to some really interesting and comical situations.
A plot twist could be that Percy's blindness is a disguise by the gods. They made him blind to protect him from a prophecy that involves his sight. As he grows up, he discovers this truth. Also, in the world of Percy Jackson, there are many magical creatures. A plot twist could be that a certain creature, like a cyclops, takes pity on him because of his blindness and becomes an unexpected ally. This cyclops could have some unique knowledge about his blindness or a way to overcome it that no one else does.
A possible plot twist could be that Naruto's blindness was actually caused by an enemy's secret jutsu that was meant to be permanent, but it turns out that Naruto's Uzumaki bloodline has a hidden ability that can reverse the blindness under certain conditions. This would add an element of mystery and hope to the story.
In the 'blind woman and doctor story', it could be that the doctor is researching on a new technology that might be able to help the blind woman. The woman has a lot of hope in this doctor and his research. The doctor faces a lot of challenges in his research, like lack of funds or difficulties in getting the right equipment. But the blind woman's faith in him gives him the motivation to keep going. And eventually, they might succeed together in finding a solution for her blindness.
Perhaps the doctor discovers that the blind woman's blindness is not a physical defect but caused by some psychological trauma. So he tries to help her overcome the psychological problem and regain her eyesight in the process of psychological counseling.
One possible plot twist could be that their love is forbidden by some ancient vampire or werewolf law. Maybe there are forces within their respective supernatural communities that oppose their union. This could lead to them having to fight for their love, and perhaps even having to go into hiding to be together.
One plot twist could be that Cream's mother, Vanilla, doesn't approve of Tails at first. She might think that Tails' love for inventions and his adventurous life with Sonic is too dangerous for Cream. Another could be that Tails accidentally creates an invention that causes him to forget his feelings for Cream. He then starts to act coldly towards her, leaving Cream heartbroken and confused.