It changes the relationship between Sasuke and Sakura significantly. Instead of the canonical relationship where they end up together, Sakura is left heartbroken. This could also lead to a change in Sakura's character, perhaps making her more independent. As for Sasuke and Karin, their relationship becomes more central and they might face different challenges together as a couple.
For one, Naruto's relationship with Sasuke might be affected in this fanfic. Naruto, who always wanted Sasuke to return to the village and be with Sakura, would be disappointed. Also, the relationship between Karin and the other members of Team Taka would change. They might be more accepting of Karin as Sasuke's choice. And overall, the dynamic between the different ninja villages could also be altered as a result of this change in relationships within the fanfic.
One possible reason could be that Karin has unique abilities that are more useful to Sasuke in his goals. For example, her sensing abilities might be crucial in his missions. Also, Karin has a deep loyalty towards Sasuke which he might value more than Sakura's feelings at that time.
It could potentially improve their relationship. Since Naruto is not involved with Sakura, there's no love triangle tension between them regarding Sakura. This might allow Naruto and Sasuke to focus more on their own friendship and mutual respect.
In some fanfictions, Sasuke and Sakura's relationship is often portrayed as a more developed romantic one. Sakura is usually shown as being deeply in love with Sasuke still, while Sasuke may be slowly coming to terms with his feelings for her. Karin's relationship with Sasuke is more complex. She has an unrequited love for him, which can create some tension. Karin and Sakura's relationship can range from being rivals to begrudging allies depending on the story.
This change would also have an impact on the other characters. Stefan, for example, might be caught in the middle. He has his own relationship with Damon and also cares about Elena. The fanfiction could create a whole new set of alliances and rivalries. Characters from the 'Twilight' series might also be involved in some way, further complicating the relationships. Overall, it would be a big upheaval in the existing relationship dynamics.
Karin could be heartbroken. She might initially be angry and feel betrayed, lashing out at Sasuke for choosing Sakura over her.
The relationship would become very tense. Naruto would likely avoid Sakura and Sasuke. There would be no more of the friendly banter or the complex emotional triangle that was there before. It's a complete shift from their normal relationships in the original story.
There could be a fanfic where Naruto, Sakura, Sasuke, and Karin wake up with a hangover after a wild celebration in the Hidden Leaf Village. Maybe they had a party to celebrate a big victory against an enemy. Naruto would probably be the first to wake up, feeling groggy but still ready to face the day. Sakura, on the other hand, might be a bit grumpy and complain about the headache. Sasuke would be his usual stoic self, but even he couldn't hide the fact that he wasn't feeling his best. Karin would be using her medical skills to try and ease the pain for everyone. It could be a humorous fanfic with lots of banter between the characters as they deal with the after - effects of their drinking.
It would definitely strain Percy's relationship with Annabeth. Annabeth would likely feel betrayed and confused. Their long - standing friendship and the romantic feelings they had for each other would be shattered. As for Percy's relationship with Reyna, it would become more complex. They would have to deal with the fallout from Percy's choice, not just from Annabeth but also from their friends and the overall demigod community.
Sakura might be heartbroken. She's been in love with Sasuke for so long. She could initially go into denial, thinking it's just a temporary thing. Then she might get angry and vow to prove herself to Sasuke, perhaps by becoming an even stronger ninja.
Naruto and Sasuke's relationship would likely become more stable. They would have to put aside their old rivalries for the sake of the 'family'. They might start to see each other as brothers - in - law in a sense. Sakura would be the bridge between them, her love for both of them in different ways helping to ease any remaining tensions. Naruto would probably become more protective of Sasuke, and Sasuke would be more open to Naruto's friendship.