In terms of her relationships with other Slytherins, the boys in the house might either be overly protective or try to take advantage of her. Some of the Slytherin girls might see her as a threat, especially if she's getting more attention from the boys or from the teachers. But there could also be a group of Slytherin girls who form a strong clique with her. And her relationship with Dumbledore could be one where he tries to encourage her to break free from the more traditional and sometimes dark Slytherin values, seeing her as a potential force for good in the house.
If Tsuna were a girl, her relationship with her male friends might become more complex. For example, some of them might develop romantic feelings for her. Her friendships with female characters could also change. They might become more competitive or more sisterly depending on the nature of the story.
With Hermione, he might see her in a new light. Instead of looking down on her as a Mudblood, he could admire her intelligence. They could work together on a project to improve the education system in the wizarding world. He would learn from her, and they could develop a mutual respect that was absent in their original world.
If Naruto were a girl, her relationship with Sasuke would likely be more complex. There could be an underlying romantic tension from the start. Sasuke might be more protective of her. And with Sakura, instead of a love triangle, they could become best friends who support each other in their ninja careers. Also, Kakashi might train her a bit differently, perhaps being more lenient at times because of her gender.
In a family setting, her relationship with her parents might also shift. Her father might become more protective, while her mother might start to have more mother - daughter type of conversations with her. And with siblings, there could be new dynamics depending on whether they are older or younger. If she has an older brother, he might be more protective too, and if she has a younger sister, they could become closer as sisters often do.
When Shirou turns into a girl, her relationships with other characters are bound to be different. Her male friends might start to see her in a more delicate way, even if she still has her old - Shirou - like strength. There could be a change in the power dynamics within the group she belongs to. Her relationships with female characters could range from being mentored by them in how to be a girl to facing competition from them. And any romantic relationships she had or hoped for would need to be re - examined, as the gender roles and expectations are now different.
If Arthas turns into a girl, her relationships with male friends might become more complex. For example, some might see her in a new, romantic light. Her friendships with female characters could also change. They might be more empathetic towards her situation or be jealous of her new - found attention.
In terms of his relationships with his Slytherin peers, some might look down on him. But others could be intrigued. Pansy Parkinson, for example, might see Draco as a girl as a threat to her status as the 'queen bee' in Slytherin. However, some of the more open - minded Slytherins could befriend Draco and help her deal with the challenges of being a girl in a very traditional and often misogynistic wizarding society.
With his Slytherin peers, Draco's relationship would shift. He might encourage them to be more inclusive and less focused on pure - blood supremacy. This could make him an outcast among some of the more traditional Slytherins, but also gain him new allies who are open to change.
Their relationship would likely become more complex. Draco, who was used to taunting Harry as a boy, might be more hesitant to do so when Harry is a girl. He could be thrown off by her new appearance and find it harder to be as cruel. There might be a sense of confusion in him.
His personality might become more empathetic. As a girl, Draco could start to see things from a different perspective. For example, he might be more sensitive to the way others are treated, especially other girls in Hogwarts.