Sasuke could also be a main character in such fanfiction. Given his rivalry with Naruto and his own powerful abilities, if he were to gain or interact with someone with sage eyes, it would create an interesting dynamic. There could be a lot of conflict and cooperation depending on how the story is written. And of course, new original characters created specifically for the fanfiction could also be main characters. They might be the ones who originally possess the sage eyes and their backstories could be deeply explored, like where they got the eyes from and what their purpose is in the Naruto - inspired world of the fanfiction.
Often, Naruto himself might be associated with it. Since he is the main character in the original series, fanfiction writers may give him sage eyes and explore how it changes his character and abilities.