Maybe there's a plot where they all get trapped in a genjutsu that makes them relive their worst memories, but they help each other break free. They realize just how much they mean to one another as they support and comfort each other during this difficult time. This could strengthen their bond even more and lead to new adventures with a stronger friendship at the core.
A really interesting plot could be that a powerful enemy targets their friendship specifically. The enemy tries to create misunderstandings between them. But Naruto, Sasuke and Sakura are smart enough to see through the lies. They then work together to defeat the enemy and prove that their friendship is unbreakable. This would involve a lot of emotional moments as well as action-packed scenes.
A really interesting plot could be that Sakura and Sasuke are transported to an alternate universe where they are the only ones from their world. They have to figure out how to get back while also dealing with the strange new world. During this time, they rely solely on their friendship. They might meet different versions of their friends and enemies, and their bond is put to the test as they make difficult decisions about whether to stay or go back to their own universe.
How about a story where an unknown enemy creates clones of them? Naruto, Sasuke, and Sakura have to not only fight these clones but also figure out who the enemy is and why they are being targeted. Along the way, they might discover new powers within themselves and also learn more about their relationships with each other.
In a fanfiction, there could be a story where a mysterious enemy targets Sasuke, Naruto and Sakura specifically because of their unique bond. The three of them then have to go into hiding and figure out who the enemy is and what they want. Along the way, they rely on each other's strengths and grow even closer as friends.
Perhaps a fanfiction where Sasuke loses his memory and Sakura has to help him regain it. She takes him back to all the places that are important to their past, like their old training grounds. As she tries to jog his memory, they end up reliving old memories and emotions, and this could lead to a rekindling of their relationship in a very emotional way.
One plot idea could be that they grow up in a hidden village where they have to face a new and powerful enemy together. As siblings, they would have a stronger bond than in the original story, which could lead to some really intense and emotional fight scenes where they protect each other at all costs.
A plot could involve time travel. Naruto and Hinata find themselves sent back in time, and they have to find a way to get back to their own time. Along the way, they meet a younger Sasuke and Sakura. This gives Naruto a chance to try and prevent some of the bad things that happened in Sasuke's past, and Hinata can bond with a younger Sakura, sharing her own experiences of growing up shy and how she overcame it.
One plot idea could be that in an alternate universe, Sasuke and Sakura have been in a relationship for a while. Naruto, being their close friend, witnesses their first real kiss during a moment of celebration after a big victory in the village. This kiss could symbolize the stability and love they've found in each other, and Naruto's reaction could be a mix of happiness for his friends and a tinge of his own loneliness.
Maybe a plot where Sasuke and Sakura go on a mission together, and Naruto's family has to step in to help when things go wrong. For example, Sasuke and Sakura are sent to investigate a strange occurrence on the outskirts of the village. But they get trapped, and Naruto's son, using his unique skills learned from his father, manages to find and rescue them, strengthening the ties between the families even more.
One plot idea could be Sai trying to understand the deep bond between Naruto, Sakura and Sasuke. He might initially struggle as he has his own unique upbringing. For example, he could be assigned a mission with the three of them and slowly learn about their history, like Naruto's determination to bring Sasuke back and Sakura's unrequited love for Sasuke in the beginning. This could lead to Sai having a new perspective on friendship and loyalty.
Perhaps in this fanfiction, they are the only ones who can stop an ancient evil that has been awakened. They are inseparable in the sense that they are constantly protecting each other. Naruto might use his Rasengan to create openings, Sasuke with his Sharingan to analyze the enemy's moves, and Sakura to heal any injuries they sustain immediately, making them an unbeatable trio.