The character of Lucian from the Underworld movies is also a very powerful werewolf. He was the first of his kind to be able to transform at will, not just during the full moon. He led the werewolves in their fight against the vampires and was extremely strong, cunning, and strategic. His leadership skills combined with his physical prowess made him a very powerful werewolf in the Underworld fictional universe.
One of the most powerful werewolves in fiction could be Fenrir Greyback from the Harry Potter series. He was a brutal and feared werewolf, known for his attacks on humans, especially children. His lack of remorse and his ability to spread his lycanthropy made him quite a formidable figure in the wizarding world.
In some fictional universes, the Alpha werewolves are considered very powerful. For example, in the Teen Wolf series, the Alphas possess enhanced strength, speed, and the ability to control other werewolves. They are at the top of the werewolf hierarchy, and their power is not only physical but also extends to having a certain level of dominance over their pack. Among them, the most powerful might be the one who has the most experience and the strongest will.