One interesting plotline could be Peter Parker struggling to control the Anti - Venom symbiote. Maybe it has a mind of its own and tries to take over Peter's actions at times. For example, it might lash out at his enemies more brutally than he intends.
Another plotline could involve the Anti - Venom symbiote having some sort of special connection to an ancient power or an otherworldly entity. Peter has to figure out how to deal with this new aspect while still being Spider - Man. It could lead to him having to make tough choices between using the Anti - Venom powers for good in a way that doesn't corrupt him.
A possible plotline is that the Anti - Venom symbiote attracts other symbiotes. Peter then has to fend off attacks from these symbiotes while also trying to understand the true nature of the Anti - Venom within him. This could create a lot of action - packed scenes as he battles multiple symbiotes at once, all while trying to keep his identity as Spider - Man a secret from the public.
Often, other symbiotes can be the main antagonists. For instance, Venom himself might see Anti - Venom (Peter) as a threat and constantly try to attack him. Venom could be jealous of the power that Anti - Venom has or simply view Peter as an enemy because of the different nature of their symbiotic relationships.
One idea could be that Peter tries to find a way to coexist with Venom without losing his own mind. He could use Venom's powers for good in a new and unique way, like being able to heal people with Venom's symbiotic abilities. Another plot could be Venom getting separated into multiple parts and Peter has to track them all down before they cause chaos. Maybe one part of Venom attaches to a villain and gives them enhanced powers that Peter has to face.
One possible plotline could be that Peter is kidnapped by a group of villains who want to use his spider - abilities for their own evil plans. They might try to force him to create some sort of super - weapon using his web - shooting and super - strength. Another plotline could be that a mad scientist kidnaps Peter to study his unique DNA and how it gives him his powers. Maybe the scientist wants to replicate the powers for himself or sell the formula to the highest bidder.
One interesting plotline could be Peter Parker coming back to find that his city has changed a great deal in his absence. Maybe new villains have emerged and he has to quickly adapt to the new threats. Another could be his relationships with his friends and family being strained after his return, and he has to work to repair them.
One idea could be that the Female Venom forms an unexpected alliance with Peter Parker. Maybe she initially has her own motives but as they interact more, she starts to see the good in Peter and his mission to protect the city. They could team up to take on a new super - villain that neither could face alone.
In some fanfics, like 'The Unexpected Ally', a plot twist could be that Venom actually has a hidden connection to Peter's family history. This completely changes the dynamic between them as they start to uncover secrets together.
At first, it would be really rocky. Peter would be very wary of Venom given their past encounters. But as Venom shows his more caring side in the adoption, Peter would start to trust him a bit. They'd have to learn to communicate, which would be difficult because of Venom's different way of thinking.
One possible plotline could be Peter dealing with the long - term aftermath of Tony Stark's death. He might struggle with living up to Tony's legacy while also trying to find his own place in the post - Endgame world. Another could be Peter exploring new relationships, whether it's with his friends at school who have also been affected by the events, or new superhero allies.
One interesting plotline could be Peter struggling to fit in with the Avengers' high - tech and super - powered world while still maintaining his normal life as a high school student. For example, he might have trouble keeping up with the Avengers' training schedules while also studying for exams.
One possible plotline could be Peter Parker dealing with the unexpected side effects of getting high while still trying to keep his identity as Spider - Man a secret. Maybe he has to fight villains while his senses are all out of whack due to the substances. Another could be his friends noticing his strange behavior and trying to figure out what's wrong with him.