The Capitol could still be the main antagonists. They might see Katniss's pregnancy as a threat, either because they fear the child could grow up to be a symbol of resistance like Katniss or just because they want to maintain control over her. They could try to harm her or the baby in some way.
Perhaps some old enemies from the Hunger Games, like the families of tributes she has defeated in the past, might emerge as antagonists. They could hold grudges and want to take revenge on her by targeting her unborn child. They might try to create situations where Katniss has to choose between her own safety and that of her baby.
Other tributes or survivors who are jealous or resentful could also be antagonists. They might not like the idea of Katniss and Finnick having a family when they have lost so much themselves. This could lead to conflict and attempts to harm them or the baby.
The Capitol would definitely be a main antagonist. They are always trying to control the tributes and the Hunger Games. With Katniss pregnant, they might see it as an opportunity to manipulate the situation for their own entertainment or to quell any potential uprisings. President Snow could be especially cruel in this scenario, using Katniss's pregnancy to threaten her and those she loves.
The Capitol officials would likely be the main antagonists. They might be the ones who create and enforce the rules of the diaper games, just like they did with the Hunger Games. They could be using these games to further control and humiliate the participants.
The main antagonists could be some of the more traditional pure - blood families who look down on Ron and Luna's relationship. They might see Luna as an oddity and Ron as not being from a high - enough status family. They could try to interfere with the pregnancy, either by spreading false rumors or trying to separate the couple.
It could be the traditional enemies from Naruto's world, like the Akatsuki. They might see the union of Naruto and Rias and their unborn child as a threat to their plans for world domination. They could try to kidnap Rias to use her as a bargaining chip against Naruto or to study the unique nature of their child.
The old enemies of Percy and Annabeth like the Titans or some of the more vengeful monsters could be the main antagonists. They might see the unborn child as a threat or an opportunity to get back at Percy and Annabeth.
Their friends could also be antagonists in a sense. For example, if there's a friend who has always had a crush on Freddie and is jealous of Sam. This friend could spread rumors about Sam being a bad influence or try to convince Freddie that he's making a huge mistake by staying with Sam and having a baby. Another scenario could be that their friends don't take the situation seriously and keep pressuring them to act like they used to, which makes it hard for Freddie and Sam to focus on the pregnancy.
It could be the jealous servants in the Beast's castle. They might not like Casey in the first place, and her pregnancy could make them fear that she will gain even more power and influence. So, they could try to sabotage her pregnancy in secret ways.
Some of the more traditional pure - blood families in the wizarding world could be antagonists. They might not approve of Harry, a half - blood, being involved with Pansy, and they could try to stop the pregnancy or break up the couple for the sake of 'pure - blood' ideals.
Another possibility is a group or organization that has different ideals. If Thalia and Luke are part of a group that values something different from them, that group could oppose their decision to have a child and become the main antagonists, trying to stop the pregnancy or take the baby away once it's born.