I think Eobard Thawne, the Reverse - Flash, could be really interesting. He could use his speed to try and steal Danny's ghost powers. His devious nature and time - traveling abilities would make him a formidable foe. He might see Danny's powers as a way to enhance his own and become even more powerful. And Danny would have to use his unique ghostly skills, like his ability to phase through objects and fly, to outwit the Reverse - Flash.
Another interesting villain could be Zoom. He's all about speed and power. In a crossover, he could target Danny, thinking that his ghost powers are a new form of energy he can absorb to become even faster. Danny would be in a tough spot, having to deal with Zoom's insane speed. The Flash would join forces with Danny, and together they'd have to come up with a plan that combines Danny's otherworldly powers and the Flash's experience with dealing with speed - based villains to take down Zoom.
The Ghost King, Pariah Dark, would be a great villain in this crossover. Imagine him getting a hold of the speed force concept from the Flash's universe. He could use it to spread his dark influence across both universes at an incredible speed. The Flash would be challenged by Pariah Dark's immense power and Danny would have to step up and use his connection to the ghost zone to find a way to stop him. It would be a battle of different kinds of powers, with the Flash's super speed against Pariah Dark's ghostly might.
The Reverse - Flash would be really interesting. He could target both Batman and the Flash. For the Flash, he's a long - time nemesis, but for Batman, he'd be a new and extremely dangerous threat. His ability to manipulate the speed force and time could put Gotham in chaos in ways Batman has never seen before. And he could use his knowledge of the Flash to try and set traps for both heroes.
It could be an evil scientist who has found a way to combine ghost and alien technology. He wants to use this to take over both the human world and the ghost zone.
The interaction between Inuyasha and Danny would be really interesting. Inuyasha is a half - demon with a hot temper, while Danny is a teenage ghost - hero who tries to keep his cool. Their different personalities would lead to some funny and tense moments. For example, Inuyasha might be impatient with Danny's more methodical approach to problem - solving. Another interesting interaction could be between Danny and Kagome. Kagome could be curious about Danny's ghost powers and modern - day knowledge, while Danny might be intrigued by Kagome's spiritual powers and her role in Inuyasha's world.
The Joker could be a great villain. Imagine him getting his hands on some ghostly technology or artifacts from Danny's world. He would use it in his own chaotic and unpredictable way, causing mayhem in Gotham and also attracting Danny's attention. Danny and Batman would have to work together to stop the Joker's mad schemes.
Kabuto could be a likely villain. He's very intelligent and has a thirst for power. He could use his knowledge of jutsu and his ability to manipulate others to try and steal The Flash's speed force. He might think that by combining it with his own powers and ninja techniques, he could become invincible.
Lex Luthor could be a great villain. He might be jealous of Supergirl's powers and see Flash as an obstacle in his plan to defeat her. He could use his scientific knowledge to create some sort of weapon that targets both speedsters and Kryptonians.
Perhaps a mad scientist from Danny's world who has somehow gotten access to Ultraman technology and is using it to create chaos. He could be creating mutant creatures that are a threat to both the Ghost Zone and Ultraman's world, and Danny and Ultraman have to stop him before it's too late.
The interactions between Ford Pines and Danny's parents could be fascinating. Ford, with his vast knowledge of the strange and supernatural, might be intrigued by Danny's parents' attempts at ghost hunting, even if their methods are a bit more primitive compared to his own scientific investigations. Meanwhile, Danny's parents might be in awe of Ford's knowledge and the things he has discovered in Gravity Falls. This could lead to some comical moments as well as some interesting exchanges of ideas about the nature of the supernatural.
I think Danny and Batman would be a really interesting pairing. Batman is all about strategy and detective work, and Danny with his ghost powers could provide a different kind of assistance. Danny might be able to use his intangibility to access places Batman couldn't, and Batman could help Danny with his combat skills and planning.
Castiel and Danny would be an unexpected but cool pairing. Castiel is an angel with his own unique powers and view of the world. Danny's half - ghost nature would be something completely new to Castiel. They could have some really deep and strange conversations about the nature of life, death, and the afterlife. And when it comes to fighting enemies, their combined powers could be really effective.