One possible plot could be that the vampires from Twilight somehow end up in the world of Glee. Maybe they are drawn there because of a unique musical energy. The Cullens could enroll in McKinley High and join the Glee club. Edward, with his musical talent, could be a star singer, but his vampire nature would cause some interesting conflicts, like how to handle his super strength during dance numbers or when handling musical instruments without breaking them.
Perhaps a spell gone wrong in the Twilight universe sends some of the characters into the Glee world. Bella, who has always been an outcast in her own way, could find a new sense of belonging in the Glee club. She might befriend Kurt, who also has had his share of feeling different. Meanwhile, the Volturi learn about this new world and see it as a potential threat or a new place to rule. This would set up a big conflict as the Glee club, along with their new Twilight friends, have to figure out how to stop the Volturi from taking over their colorful and musical world.
A plot could involve the werewolves from Twilight also being part of the crossover. They could sense some sort of danger in Lima, Ohio (where Glee is set) related to the supernatural. So they come to protect the town. Meanwhile, the Glee club members are intrigued by these new, mysterious students. Rachel could be especially fascinated by Edward's brooding nature and try to write a song about it, while the werewolves and vampires have an uneasy truce as they both deal with the chaos of high school and the Glee club's competitions.
One possible plot could be that the Supergirl characters find themselves in the world of Glee. Maybe Kara has to blend in at McKinley High while also dealing with her superpowers. She could join the glee club and use her super - hearing to help them perfect their harmonies. And she might have to face off against some villains who are after her while trying not to expose her true identity to her new friends in the glee club.
One possible plot could be that Wolverine somehow ends up in the Twilight universe. Maybe he's on a mission that goes wrong and he gets transported there. He then meets the vampires and werewolves in Twilight. The vampires might be intrigued by his healing factor and his adamantium claws. And the werewolves could see him as either a threat or an ally. He could get caught in the middle of the conflict between the Cullens and the Volturi, using his combat skills to tip the balance.
Perhaps Bella could be a key figure in a crossover. She could be a 'dragon rider' in a sense, using her connection with Edward (similar to the bond between a dragon and its rider in Game of Thrones). Her immunity to vampire powers could translate to some sort of immunity to the dark magic in Westeros. The werewolves from Twilight could be allies with the Stark direwolves, and together they fight against common enemies, like an army of the dead led by a Volturi - like figure.
One possible plot could be that the Volturi from Twilight discover the existence of demigods from the Percy Jackson world. They see the demigods as a threat to their vampire supremacy. Percy and his friends have to team up with some of the more friendly vampires, like the Cullens, to fend off the Volturi. This would bring together the magic and powers of both universes in an epic battle.
A possible plot is that the Capitol in the Hunger Games discovers the existence of vampires from Twilight. They see them as a new form of entertainment and try to capture them to put in the arena. However, the vampires are not so easily controlled. Katniss and her allies could team up with the vampires against the Capitol. This would bring together the themes of rebellion from Hunger Games and the supernatural elements of Twilight.
Well, perhaps in this 'immortal ichigo twilight crossover fanfiction', Ichigo arrives in the Twilight world during a time of great unrest. The Volturi are on the verge of a major power play. Ichigo's immortality gives him an edge in this dangerous new world. He teams up with Bella and Edward. Ichigo's combat skills and reiatsu powers could be a huge asset against the Volturi's army. They could form an unlikely alliance to protect Forks and the rest of the world from the Volturi's tyranny.
One possible plot could be that Inuyasha somehow gets transported to the Twilight world. He might initially be confused by the modern settings and the presence of vampires and werewolves. Bella could mistake him for a new type of supernatural being. And Inuyasha, with his sword and combat skills, could get involved in the ongoing feud between the Cullens and the werewolves in Forks.
Perhaps the mummy has a power that can affect vampires in some way, like weakening their abilities. In this Twilight and the Mummy crossover fanfiction, the Cullens could team up with some mummy - hunters to find a way to neutralize this threat. They might have to travel to ancient tombs and decipher hieroglyphics to find a solution, all while dealing with other vampires or supernatural beings who want to use the mummy's power for themselves.
One idea could be that the vampires in Twilight somehow find their way into the wizarding world of Harry Potter. Maybe they are initially mistaken for dark creatures and there's a big misunderstanding. Harry and his friends have to figure out that they are not really a threat like the Death Eaters. They could then team up to fight a common enemy, like a new breed of dark magic - using the powers of both wizards and vampires.
One possibility could be that Christian Grey has some business dealings in Forks. There, he meets Bella. He's intrigued by her shyness and her unique relationship with Edward. Maybe Christian tries to court Bella in his own dominant way, which causes tension between her and Edward. Edward becomes overly protective, seeing Christian as a threat to his relationship with Bella.