Sure. 'Scythe' by Neal Shusterman has a female protagonist. In this world, Scythes are in charge of controlling the population. The main character has to navigate a complex world of rules and ethics related to this power. It involves some technological and scientific concepts about how the world functions in the story.
'The House of the Scorpion' by Nancy Farmer has a strong female character. The story is set in a future where clones are created for organ harvesting. The main character has to fight against this cruel system. It involves some biological and technological concepts related to cloning and the power dynamics in the society.
'A Wrinkle in Time' by Madeleine L'Engle features a girl named Meg. It's a classic that combines science - fiction elements like time travel and different dimensions. Meg goes on a journey to save her father with the help of some mysterious beings. It's a great exploration of physics concepts in a young adult - friendly way.