The main theme could be about the complex human relationships in the context of Mississippi. It might explore family, friendship, or love among the characters living in that region.
Maybe it's about the idea of blood in a metaphorical sense. Blood can represent family ties, so perhaps the novel delves into family secrets, loyalty, and the bonds that hold families together or tear them apart. In the context of Mississippi, these family dynamics could be influenced by the local customs, social hierarchies, and economic situations. It could also be about the bloodshed or conflicts that have occurred in Mississippi's history and how they still have an impact on the present - day characters in the story.