In some GTA 5 My Little Pony fanfiction, it could be that a pony has to adapt to the fast - paced and often violent life in GTA 5. The contrast between the pony's gentle and colorful world and the gritty world of GTA 5 can create a lot of interesting scenarios. For example, a pony might try to bring peace to the crime - ridden streets of Los Santos using its special abilities. This would involve interactions with various GTA 5 characters, and the resulting cultural clash and attempts at understanding each other could form a really engaging story.
There might be a fanfiction where the GTA 5 characters encounter a group of ponies. The ponies' positive and friendly nature could start to change the way the GTA 5 characters view the world around them. They could learn about friendship from the ponies, which is a big theme in My Little Pony, and this could lead to some really unique story developments.