The Akatsuki could be the main antagonist. They might see Hanzo as an easy target after Naruto abandons him and try to capture him for their own purposes, like using his knowledge of the ninja world or his unique abilities.
It could be the elders of his clan. They are often the ones who make decisions in the clan, and if they see Naruto as a threat for whatever reason, they could be the main antagonists. They might be afraid of Naruto's growing power or his different way of thinking that could disrupt the traditional ways of the clan.
It could be Danzo. He's always been a bit of a shadowy figure in the Naruto series. Maybe he sees Naruto as a threat to his power and influence in the village and manipulates the situation so that Team 7 has to abandon him. He would be a great main antagonist as he has the resources and the motives to cause such a rift in Team 7.
Maybe the main antagonist is the entire Iwa council. They might be the ones who order Naruto's abandonment because they fear his potential influence on Iwa. They would do everything in their power to keep him from uncovering their plans or causing unrest among the villagers.
It could be someone from the village who doesn't want Naruto to discover the truth about his parents. Maybe they fear that if Naruto finds out certain secrets, it will disrupt the power balance in the village.
It could be a relative from his family who was behind the abandonment. Maybe they want to keep Naruto away from some family secret or power, and they will do anything to stop him from finding out the truth.
Perhaps the main antagonist is actually an old enemy who manipulates Naruto's team into abandoning him. This enemy could be using mind - control or false information to drive a wedge between Naruto and his team. They do this to weaken Naruto, knowing that his strength comes from his relationships.
Perhaps it could be another entity related to Hagoromo. If Naruto abandons Hagoromo, there might be a counterpart or a follower of Hagoromo who sees Naruto as a threat or a traitor. This person could then become the main antagonist, trying to either bring Naruto back to Hagoromo's side or simply eliminate him.
The main antagonist could be the Hidden Leaf Village itself. Since Naruto was abandoned by Kushina, the village that failed to take proper care of him could be seen as the enemy. The village elders or those in power who turned a blind eye to his suffering could be the ones he has to oppose.
Another possibility is that some rogue ninja who have a vendetta against Hanzo might target Naruto as a way to get back at Hanzo. They could see Naruto as Hanzo's weakness and try to harm or kidnap him, which would then lead to a series of battles and confrontations in the fanfiction.
The main antagonist might be a dark wizard or sorcerer who has a long - standing feud with the dragon. When Naruto is abandoned and finds the dragon, this antagonist sees Naruto as an easy target to get to the dragon. They might try to manipulate Naruto or directly attack him to get the dragon under their control. Also, it could be a group of rogue ninjas who want to use the dragon's power to take over the ninja world and view Naruto as a hindrance since he has a bond with the dragon.