John Connor could also be extremely powerful. In the Terminator universe, he's a natural leader and a skilled fighter against the machines. If he were introduced to Mass Effect technology like biotics or the Mass Relays, he could use it to his advantage. He might even be able to unite the different species in the Mass Effect universe against a common threat, like a rogue group of Terminators or some new combined threat that emerged from the collision of the two universes.
The Catalyst from Mass Effect might also be a very powerful entity in such a crossover. It has control over the Reapers and a vast understanding of synthetic and organic life. In a collision with the Terminator universe, it could potentially manipulate or even control the Terminators, as they are machines. It could use them to further its own goals, whatever those might be in this new combined scenario.
It's hard to say for sure, but Naruto himself could be a very powerful contender. His vast array of jutsu and his ability to harness the Nine - Tails' power would make him extremely formidable. He could easily take on many opponents at Marineford with his shadow clones and powerful attacks like the Tailed Beast Bomb.
It could be Danny. His ghost powers give him a wide range of abilities like flight, intangibility, and ectoblasts. In the Digital World, these powers would be very useful. He could also phase through digital barriers and surprise his enemies. Also, his ability to overshadow people or Digimon could give him an edge in battles.
It's likely the Doom Slayer. He has proven to be an unstoppable force against hordes of demons. His strength, speed, and arsenal of weapons make him a formidable opponent. In a collision with Warhammer 40K, he could take on many of the threats there as well.
It's hard to say, but Sasuke could be a really powerful character in such a crossover. His Sharingan abilities combined with possible bending skills could make him a formidable force. He could use the Sharingan to predict an opponent's bending moves and counter them effectively.
If we consider the powers and abilities in both universes in a fanfiction context, I think it could be Eri from My Hero Academia. Her quirk has the potential to be extremely powerful as it can rewind a person's body to a previous state. If she could learn to control it fully, she could potentially 'undo' the powerful undead in the Overlord universe or even reverse the magic spells. However, this is a very speculative idea as she is still a young and inexperienced character, and the power of Ainz Ooal Gown and his allies in the Overlord world should not be underestimated.
Another strong contender could be Raiden. As a thunder god in Mortal Kombat, he has control over lightning and has great combat skills. In the Harry Potter universe, his lightning attacks could be very difficult to defend against. He could also use his powers to disrupt magic, as electricity can interfere with magical devices. His immortality also gives him an advantage, as he can keep coming back in a fight no matter how much damage he takes.
Magneto might also be extremely powerful in such a crossover. His ability to control metal could be a huge advantage in the wizarding world. He could manipulate the metal in wands, cauldrons, and other magical objects. However, he would have to deal with the unique magic that doesn't rely on physical elements all the time.
If we consider the character of Harry Potter himself, his ability to resist the Killing Curse and his connection to the Deathly Hallows could make him a formidable force. In the world of Bioshock Infinite, he could use his magic to protect the oppressed and fight against the tyrannical rule in Columbia. His courage and the power of love, which are important themes in his own story, could also play a significant role in this crossover scenario, perhaps even influencing the characters in Bioshock Infinite in unexpected ways.
However, Voldemort also has a claim to being the most powerful. His dark magic is extremely potent, and if he were to enter the Game of Thrones world, he could use fear and intimidation to gain power. He might even form alliances with some of the more ruthless characters in Westeros to achieve his goals.
Sora would be a very powerful contender. He has a lot of experience fighting all kinds of enemies in different worlds in Kingdom Hearts. His Keyblade skills and ability to use magic would give him an edge. Also, he has the power of the heart on his side. But Izuku Midoriya with One For All at its full potential could also be extremely powerful. He has incredible strength and speed, and his determination is unwavering.