Perhaps it could be about a physical competition where the fact that Angel is heavier gives him an advantage or disadvantage. For example, if they are in a situation where they have to carry something heavy or cross a weak bridge. It could also explore how they support each other in this situation, with Gunn using his agility and Angel his strength.
Another storyline could revolve around a magical or supernatural reason for Angel being heavier. It might be related to a spell or a curse that affects his physical form. Gunn could be on a quest to find a way to break this spell, leading to an adventure where they face various obstacles and enemies together, all while dealing with the implications of Angel's abnormal weight.
One possible storyline could be that the difference in their weights is used as a metaphor for their inner struggles. Maybe Angel, being heavier, is burdened with more emotional baggage, like his past sins as a vampire. And Gunn, being lighter, represents a more carefree or less complex character at the start, but as the fic progresses, he takes on more weight in terms of responsibilities or moral dilemmas.