I think Mirabel from Encanto and Aang from Avatar would be likely to interact. Mirabel is all about finding her place in the family and Aang is on a journey to save the world. They could share their experiences of feeling different and having big responsibilities.
Naruto and Aang would be the most obvious ones. They are the main characters in their respective worlds.
Death from DarkSiders and Black Widow could have an interesting interaction. Death has seen countless deaths and has a very different perspective on life and death compared to the human Black Widow. Their conversations could be deep and thought - provoking as they work together on a mission.
I think Naruto and Optimus Prime would be likely to interact. Naruto is the main character in his world, always looking for ways to protect his friends and village. Optimus Prime is the noble leader of the Autobots. Their leadership qualities and sense of justice would make them natural allies. They could share their experiences and strategies in fighting against evil.
I think Quinn and Black Widow would be an interesting pair. Quinn is used to being in a position of power and popularity in the Glee club, and Black Widow is a strong female character in the Avengers. They could have some really cool exchanges about strength and femininity.
Spyro and Twilight Sparkle would be likely to interact. Twilight is very intelligent and well - versed in magic, and Spyro has his own dragon powers. They could learn from each other. For example, Twilight could study Spyro's dragon magic, and Spyro could learn about the complex magic system in Equestria from Twilight.
Harry Potter himself could interact with Sophie from Huntik. Harry is used to facing great challenges and having a strong sense of justice. Sophie, with her connection to the Titans, could find common ground with Harry in their fight against evil. They could learn from each other's worlds and work together to overcome a powerful dark force that threatens both universes.
I think Sakura from Naruto and Stella from Winx could interact a lot. Sakura is a strong - willed and intelligent kunoichi, and Stella is a confident and powerful fairy. They could have some really interesting conversations about their respective worlds, like comparing the medical ninjutsu in Naruto's world to the healing magic in the Winx world. And they might also get into some friendly rivalries while training together.
In my opinion, Kakashi from Naruto would be an interesting character to interact with Tuff Puppy. Kakashi's calm and collected nature combined with his powerful ninja skills could create some cool scenes when paired with Tuff's more energetic and comical style. And of course, Shikamaru's intelligence would make for an interesting interaction with any of the characters in Tuff Puppy's world who need some smart thinking to solve a problem.
Naruto and Star - Lord would be likely to interact. Naruto's friendly and outgoing nature would draw him to Star - Lord's charisma. They both have a sense of adventure and a desire to protect their own groups. Naruto might be curious about Star - Lord's blasters and spaceship, while Star - Lord could be interested in Naruto's ninjutsu.
Definitely Ruby Rose and Master Chief. Ruby is the main character in RWBY, full of energy and determination. Master Chief is a well - known and iconic figure in Halo. Their different personalities and combat styles would create an interesting dynamic. Ruby's quick - thinking and agility could pair well with Master Chief's stoic and strategic approach in battles.