One characteristic is that they often have more freedom in storytelling. For example, 'Psycho - Pass' was an original anime. Without the constraints of adapting a pre - existing work, it could create a complex and unique world with its own rules regarding the Sibyl System. It didn't have to worry about staying true to a manga or light novel's plot, so it could take risks and be more experimental.
They can also have a more distinct visual style. Take 'Redline' for instance. It's an anime that's not based on other works. It has a highly stylized and detailed art style that's all its own. The animators had the creative freedom to design the world, the characters, and the vehicles in a way that might not have been possible if they were adapting from a manga or light novel. Since they didn't have to match a pre - existing visual aesthetic, they could go all out.