Tsunade could be a significant character. As the Hokage and a medical expert like Sakura, she could have some knowledge about the crystal. She might offer advice or warnings to Sakura. Then there's Shizune, who could assist Tsunade in dealing with Sakura and the crystal situation. And of course, Orochimaru might be a potential villain, interested in the crystal's power for his own dark experiments.
Well, Naruto would be a likely character. He and Sakura are friends, and he'd probably be really worried about her. He might visit often and try to cheer her up with his goofy antics. Another could be Sasuke. Even if he's a bit more aloof, his presence would add an interesting dynamic. He could come to see her out of his own sense of obligation or perhaps a deeper, unspoken feeling.
There could be some original characters created specifically for this fanfiction. Maybe a mysterious mentor figure who claims to be able to help Sakura control her dark side, but has their own ulterior motives. Also, her sensei Kakashi could be there, trying to figure out how to guide Sakura through this difficult time.
It could be Naruto. Since he has always been a big part of Sakura's life, he might be one of the main characters trying to figure out what's wrong with Sakura and how to bring back the old her.
One character could be Naruto. He might be Sakura's friend, but completely oblivious to her hidden pain. He's so focused on his own goals that he doesn't notice Sakura's struggle, which could add to her feelings of loneliness.
Naruto could be a great addition. His friendship with Sakura and his complex relationship with Kabuto in the original series could add an interesting dynamic. For example, Naruto might suspect something is going on between Sakura and Kabuto and try to interfere or understand what's happening.
There could be the patients, of course. Each patient might have their own unique backstory and personality. Maybe there's a young patient who is dealing with trauma, and Sakura has to find a way to reach out to them.
One potential ally could be Naruto. Even though he may not be part of the Anbu, his strength and determination could make him a valuable ally in certain situations. He might help Sakura out when she's in a tight spot during an Anbu mission. Another could be Kakashi. He has a lot of experience in the ninja world and could offer guidance and support to Sakura in the Anbu. Also, Shikamaru with his intelligence could be an ally. He could help with strategic planning for Anbu operations that Sakura is involved in.
Amu Hinamori would be a great character to pair Sakura with. Amu has her own set of Shugo Chara and a strong personality. Together, they could share their experiences with their Shugo Chara and learn from each other. Their different yet complementary personalities could lead to some really interesting interactions and adventures.
I don't know for sure, but since it's a fanfiction centered around Sakura Haruno, she is the main focus. However, it may also feature characters who had a major impact on her life. This could include her sensei, like Tsunade, who trained her in medical ninjutsu. There's also a possibility that new characters created specifically for this fanfiction could be main characters as well, but that's just speculation.
In some Sakura Haruno alpha fanfiction, Kakashi could be a significant character. He might act as a mentor to Sakura in her new alpha role. He could guide her in making difficult decisions, like when she has to choose between the safety of the village and the life of a comrade.