Shikamaru is a likely candidate. Given his intelligence, he could be the one who figures out Naruto's pranks quickly and tries to either foil them or help Naruto make them even better. He might see Naruto's pranks as an interesting diversion from the normal routine.
Sasuke could be one of the main characters. He might be initially annoyed by Naruto's pranks but then end up getting involved in some way, either trying to stop Naruto or joining in on the fun.
Well, it could be that Naruto pranks the clans to test their reactions and sense of humor. Maybe he uses simple tricks like fake summons or changing the appearance of clan symbols to see how they respond.
Sakura could be a great main character. You could show her growth during the bell test, not just as a ninja in terms of skills, but also in her self - confidence. Maybe she has to take the lead when Naruto and Sasuke are incapacitated for some reason.
Sasuke could be a major character. Since Naruto and Sasuke have such a complex relationship, Sasuke might be the one to go after Naruto. Or he could be dealing with his own issues in the Hidden Leaf in Naruto's absence, which could be an interesting sub - plot.
Iruka Sensei might be important too. He was one of the first people to show kindness to Naruto. He could be a key figure in making the village understand that Naruto is worth having back. Also, Sasuke might be involved. If he has reconciled with the village, he could see the value of Naruto's return and help in the process.
One of the interesting pranks could be Naruto disguising as a clan elder and giving out really strange and comical orders. For example, he might tell the Uchiha clan to start wearing pink headbands for a week just to see their confused reactions.
There could be a new character introduced, perhaps an old hermit who is an expert in sealing. This character could have some hidden motives, like using Naruto's newfound skills for his own gain at first but then eventually becoming a true ally after seeing Naruto's pure intentions with the power of sealing.
It's hard to say without reading the fanfic, but it could be characters like Sasuke. Since Sasuke is Naruto's rival, he might be involved, either competing with Naruto over the use of the Raijin no Ken or joining forces with him. Kakashi is also a likely character to be in it as he has knowledge about many ninja techniques and could play a role in guiding Naruto in using the weapon.
Hinata could be an idol trainee. She is shy at first but as she trains, she becomes more confident. Naruto could be her biggest supporter, and their relationship could develop further as they both pursue their dreams in the idol and ninja worlds respectively.
There could be members of the Gremory family. For example, Rias Gremory might be a key character. She could be one of those who initially neglect Naruto but later come to realize his potential. Another character could be Issei Hyodo, who might be in a position where he has to choose between the traditional Gremory way and Naruto's different approach.
Obviously Naruto would be the main character as it's about him being the 'god of pranks'. His friends like Sasuke, Sakura, and Kakashi are likely to be important characters too. Sasuke might be the target of many of Naruto's pranks, which could add some humorous tension between them. And Kakashi, as Naruto's teacher, might be constantly trying to stop Naruto's pranks or get caught up in them.