I'm not entirely sure specifically what this 'fear and loathing graphic novel' is about without more context. However, generally, in a graphic novel, 'fear and loathing' could involve exploring the darker aspects of human nature, like paranoia, hatred, or fear of the unknown. It may use vivid illustrations to bring out these emotions and the story.
It's likely about themes of fear and loathing presented in a graphic novel format. It might tell a story full of strange characters and events that evoke these emotions. For example, it could be a journey of a character through a dystopian world where they encounter various terrors and things they loathe.